Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways (Q44549002)

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scientific article published in August 2003

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English	Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways	scientific article published in August 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 December 2017

Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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Kazuma Ohyashiki

8

object named as

Kazuma Ohyashiki

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4 December 2017

author name string

Tetsuzo Tauchi

1

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4 December 2017

Kazuo Shin-Ya

2

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4 December 2017

Goro Sashida

3

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4 December 2017

Masahiko Sumi

4

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4 December 2017

Akihiro Nakajima

5

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4 December 2017

Takashi Shimamoto

6

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4 December 2017

Junko H Ohyashiki

7

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4 December 2017

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publication date

1 August 2003

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4 December 2017

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4 December 2017

22

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4 December 2017

34

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5338-5347

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4 December 2017

Telomere maintenance mechanisms as a target for drug development

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A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

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For better or worse? Telomerase inhibition and cancer

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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Telomere maintenance by recombination in human cells.

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Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides.

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability

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Inhibition of telomerase limits the growth of human cancer cells.

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Telomere loss: mitotic clock or genetic time bomb?

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

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Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

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The genetic defect in ataxia-telangiectasia

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Telomere dysfunction alters the chemotherapeutic profile of transformed cells

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Role of telomerase in normal and cancer cells

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ABL-specific tyrosine kinase inhibitor, STI571 in vitro, affects Ph-positive acute lymphoblastic leukemia and chronic myelogenous leukemia in blastic crisis

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Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy

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Telomeres and telomerase in hematologic neoplasia

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Recent advances in the development of telomerase inhibitors for the treatment of cancer

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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The nuclear tyrosine kinase c-Abl negatively regulates cell growth

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Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase

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Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Inhibition of telomerase by G-quartet DNA structures

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant

1 reference

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7 January 2021

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Inhibition of human telomerase by a G-quadruplex-interactive compound

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7 January 2021

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Identifiers

10.1038/SJ.ONC.1206833

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Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

ResearchGate publication ID

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