Mechanisms of pathogenicity in human MSH2 missense mutants. (Q43919200)

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25 December 2019

title

Mechanisms of pathogenicity in human MSH2 missense mutants (English)

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25 December 2019

1

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25 December 2019

Minna Nyström

series ordinal

4

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25 December 2019

author name string

Denis Dermadi Bebek

series ordinal

2

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25 December 2019

Josef Jiricny

series ordinal

3

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25 December 2019

publication date

1 November 2008

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25 December 2019

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25 December 2019

volume

29

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25 December 2019

issue

11

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25 December 2019

page(s)

1355-1363

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The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications

25 December 2019

cites work

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Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer

21 January 2018

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Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer.

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Clues to the pathogenesis of familial colorectal cancer

21 January 2018

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7 January 2021

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

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7 January 2021

MutS mediates heteroduplex loop formation by a translocation mechanism

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7 January 2021

Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism

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7 January 2021

Steady-state regulation of the human DNA mismatch repair system.

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7 January 2021

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

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7 January 2021

Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSalpha is abolished by a single mutation in the hMSH6 subunit

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7 January 2021

Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.

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7 January 2021

The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular Switch

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7 January 2021

hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

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7 January 2021

The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch

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7 January 2021

New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing

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7 January 2021

hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha

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7 January 2021

Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer

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7 January 2021

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches

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7 January 2021

Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome

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7 January 2021

MSH6 missense mutations are often associated with no or low cancer susceptibility

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7 January 2021

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

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7 January 2021

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

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7 January 2021

Tumours from MSH2 mutation carriers show loss of MSH2 expression but many tumours from MLH1 mutation carriers exhibit weak positive MLH1 staining

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7 January 2021

Development of Colorectal Tumors in Colonoscopic Surveillance in Lynch Syndrome

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7 January 2021

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

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7 January 2021

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

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7 January 2021

Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein

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7 January 2021

Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification.

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7 January 2021

Functional analysis helps to clarify the clinical importance of unclassified variants in DNA mismatch repair genes

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7 January 2021

hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

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7 January 2021

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7 January 2021

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

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7 January 2021

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

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7 January 2021

Structure of the human MutSalpha DNA lesion recognition complex

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7 January 2021

A new variant database for mismatch repair genes associated with Lynch syndrome

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7 January 2021