Cbl-mediated ubiquitinylation and negative regulation of Vav. (Q43578123)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12881521%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Cbl-mediated ubiquitinylation and negative regulation of Vav (English)

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6 November 2019

7

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6 November 2019

Robert Rottapel

6

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6 November 2019

author name string

Yuko Miura-Shimura

1

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6 November 2019

Lei Duan

2

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6 November 2019

Navin L Rao

3

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6 November 2019

Alagarsamy L Reddi

4

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6 November 2019

Hideki Shimura

5

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6 November 2019

Alexander Tsygankov

8

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6 November 2019

Vimla Band

9

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6 November 2019

Hamid Band

10

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6 November 2019

language of work or name

English

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publication date

24 July 2003

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Journal of Biological Chemistry

6 November 2019

published in

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6 November 2019

volume

278

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issue

40

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6 November 2019

page(s)

38495-38504

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

6 November 2019

cites work

1 reference

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Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

21 January 2018

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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 January 2018

1 reference

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Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

21 January 2018

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The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

21 January 2018

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

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Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

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RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

21 January 2018

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The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

21 January 2018

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The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

21 January 2018

1 reference

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Negative regulation of Lck by Cbl ubiquitin ligase

21 January 2018

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Ubiquitin-dependent degradation of active Src.

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

21 January 2018

1 reference

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells

21 January 2018

1 reference

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Beyond the RING: CBL proteins as multivalent adapters

21 January 2018

1 reference

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

21 January 2018

1 reference

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

21 January 2018

1 reference

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Signal transduction in T lymphocytes using a conditional allele of Sos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

A functional T-cell receptor signaling pathway is required for p95vav activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells

21 January 2018

1 reference

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Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

21 January 2018

1 reference

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Lck regulates Vav activation of members of the Rho family of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

21 January 2018

1 reference

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

The structure of an antigenic determinant in a protein

21 January 2018

1 reference

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Oncogenes, growth factors, and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells

21 January 2018

1 reference

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Structure and functions of the 20S and 26S proteasomes

21 January 2018

1 reference

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21 January 2018

1 reference

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

21 January 2018

1 reference

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Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305656200

21 January 2018

Identifiers

DOI

10.1074/JBC.M305656200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12881521%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference