Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin (Q42792741)

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scientific article published on January 15, 1992

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English	Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin	scientific article published on January 15, 1992

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scholarly article

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Europe PubMed Central

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7 November 2017

Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin (English)

1 reference

10.1042/BJ2810553

https://api.crossref.org/works/10.1042/BJ2810553

12 November 2022

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based on heuristic

inferred from title

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10.1042/BJ2810553

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12 November 2022

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10.1042/BJ2810553

https://api.crossref.org/works/10.1042/BJ2810553

12 November 2022

author name string

M. Patel

1

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12 November 2022

I. S. Kayani

2

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12 November 2022

G. W. Mellor

3

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12 November 2022

S. Sreedharan

4

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12 November 2022

W. Templeton

5

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12 November 2022

E. W. Thomas

6

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M. Thomas

7

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12 November 2022

K. Brocklehurst

8

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12 November 2022

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publication date

1 January 1992

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7 November 2017

15 January 1992

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12 November 2022

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1736903/?tool=EBI

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12 November 2022

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1736903/pdf/?tool=EBI

online access status

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12 November 2022

https://europepmc.org/articles/PMC1130721

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Europe PubMed Central

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Europe PubMed Central

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12 November 2022

https://europepmc.org/articles/PMC1130721?pdf=render

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Europe PubMed Central

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12 November 2022

https://portlandpress.com/biochemj/article-pdf/281/2/553/606072/bj2810553.pdf

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10.1042/BJ2810553

https://api.crossref.org/works/10.1042/BJ2810553

12 November 2022

Biochemical Journal

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7 November 2017

281 ( Pt 2)

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Europe PubMed Central

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7 November 2017

553-559

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Europe PubMed Central

PMC publication ID

7 November 2017

MECHANISM OF ACTION OF PROTEOLYTIC ENZYMES.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Statistical estimations in enzyme kinetics

1 reference

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27 May 2018

Differences in the interaction of the catalytic groups of the active centres of actinidin and papain. Rapid purification of fully active actinidin by covalent chromatography and characterization of its active centre by use of two-protonic-state reac

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Structure of papain refined at 1.65 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Structure of papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

The amino acid sequence around the active-site cysteine and histidine residues, and the buried cysteine residue in ficin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

pH-dependence and structure-activity relationships in the papain-catalysed hydrolysis of anilides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Kinetic specificity in papain-catalysed hydrolyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain

1 reference

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27 May 2018

Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding

1 reference

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27 May 2018

Designing substrate specificity by protein engineering of electrostatic interactions

1 reference

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27 May 2018

Tinkering with enzymes: what are we learning?

1 reference

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27 May 2018

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics

1 reference

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27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe stu

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Kinetics of binding of chicken cystatin to papain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1130721

27 May 2018

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides

1 reference

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27 May 2018

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition

1 reference

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Reversible binding of peptide aldehydes to papain. Structure-activity relationships

1 reference

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Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites

1 reference

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The pre-eminence of k(cat) in the manifestation of optimal enzymic activity delineated by using the Briggs-Haldane two-step irreversible kinetic model

1 reference

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Binding of chloromethyl ketone substrate analogues to crystalline papain

1 reference

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Evolution of enzyme catalytic power. Characteristics of optimal catalysis evaluated for the simplest plausible kinetic model

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Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the pa

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Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe

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Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering

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Structure of actinidin, after refinement at 1.7 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/1736903

12 December 2020

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Redesigning trypsin: alteration of substrate specificity

1 reference

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Interaction between chicken cystatin and the cysteine proteinases actinidin, chymopapain A, and ficin

1 reference

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The kinetic analysis of hydrolytic enzyme catalyses: Consequences of non-productive binding

1 reference

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Cysteine proteases: the S2P2 hydrogen bond is more important for catalysis than is the analogous S1P1 bond

1 reference

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The preparation and properties of two new chromogenic substrates of trypsin

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The pH‐Dependence of Rates of Individual Steps in Ficin Catalysis

1 reference

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Identifiers

10.1042/BJ2810553

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 November 2017

ResearchGate publication ID

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