The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats (Q42705053)

5 November 2017

title

The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats (English)

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5 November 2017

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Liang Chen

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author name string

Shangchun Li

1

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5 November 2017

Jun Chen

2

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5 November 2017

Ping Xie

3

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5 November 2017

Xiaochun Guo

4

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5 November 2017

Huihui Fan

5

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5 November 2017

Dezhao Yu

6

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5 November 2017

Cheng Zeng

7

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5 November 2017

publication date

25 June 2014

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5 November 2017

published in

Environmental Toxicology

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5 November 2017

volume

30

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issue

12

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5 November 2017

page(s)

1470-1480

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

5 November 2017

cites work

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The interactive effects of cytoskeleton disruption and mitochondria dysfunction lead to reproductive toxicity induced by microcystin-LR.

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Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity

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Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes.

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Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon

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Microcystin-LR-induced ultrastructural changes in rats

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Activity and gene expression profile of certain antioxidant enzymes to microcystin-LR induced oxidative stress in mice

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Formation, characterization, and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins

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Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish.

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A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease

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Rapid conversion and reversible conjugation of glutathione detoxification of microcystins in bighead carp (Aristichthys nobilis).

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Regulation of glutathione synthesis

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Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes

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Comparison of in vivo and in vitro toxic effects of microcystin-LR in fasted rats

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Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally.

21 January 2018

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Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

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Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication.

21 January 2018

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The profound effects of microcystin on cardiac antioxidant enzymes, mitochondrial function and cardiac toxicity in rat.

21 January 2018

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Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: its relation to liver lipid composition.

21 January 2018

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Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection

21 January 2018

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A novel model of continuous depletion of glutathione in mice treated with L-buthionine (S,R)-sulfoximine

21 January 2018

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Sequential ultrastructural and biochemical changes induced by microcystin-LR in isolated perfused rat livers.

21 January 2018

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Acute effects of microcystins exposure on the transcription of antioxidant enzyme genes in three organs (liver, kidney, and testis) of male Wistar rats.

21 January 2018

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Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae

21 January 2018

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The role of reactive oxygen species in microcystin-LR-induced DNA damage

21 January 2018

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Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells

21 January 2018

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Determination of microcystin-LR and its metabolites in snail (Bellamya aeruginosa), shrimp (Macrobrachium nipponensis) and silver carp (Hypophthalmichthys molitrix) from Lake Taihu, China.

21 January 2018

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Hematological and plasma biochemical responses of crucian carp (Carassius auratus) to intraperitoneal injection of extracted microcystins with the possible mechanisms of anemia

21 January 2018

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The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR.

21 January 2018

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Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/TOX.22017

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5 November 2017

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