Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. (Q42511286)

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11 February 2020

title

Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain (English)

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11 February 2020

3

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11 February 2020

Martin Puskarjov

series ordinal

1

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11 February 2020

Faraz Ahmad

series ordinal

2

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11 February 2020

author name string

Peter Blaesse

series ordinal

4

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11 February 2020

language of work or name

English

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publication date

1 August 2012

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11 February 2020

published in

Journal of Neuroscience

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11 February 2020

volume

32

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issue

33

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11 February 2020

page(s)

11356-11364

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describes a project that uses

11 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6621186/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Calpain inhibitor I retards seizure offset in the hippocampus of freely moving rats

1 reference

12 December 2020

A furosemide-sensitive K+-Cl- cotransporter counteracts intracellular Cl- accumulation and depletion in cultured rat midbrain neurons.

1 reference

12 December 2020

Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model

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12 December 2020

BDNF and epilepsy: too much of a good thing?

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12 December 2020

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition

1 reference

12 December 2020

The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus.

1 reference

12 December 2020

Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

1 reference

12 December 2020

The influence of cycloheximide on Na,K-ATPase activity in cultured human lens epithelial cells.

1 reference

12 December 2020

BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion

1 reference

12 December 2020

A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.

1 reference

12 December 2020

Cation-chloride co-transporters in neuronal communication, development and trauma

1 reference

12 December 2020

A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation

1 reference

12 December 2020

Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2.

1 reference

12 December 2020

Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission

1 reference

12 December 2020

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.

1 reference

12 December 2020

Interactions of postsynaptic density-95 and the NMDA receptor 2 subunit control calpain-mediated cleavage of the NMDA receptor.

1 reference

12 December 2020

Imaging calpain protease activity by multiphoton FRET in living mice

1 reference

12 December 2020

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

1 reference

12 December 2020

Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices

1 reference

12 December 2020

Prolonged seizures and cellular injury: understanding the connection

1 reference

12 December 2020

A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport

1 reference

12 December 2020

Calpain sensitive regions in the N-terminal cytoplasmic domains of glycine transporters GlyT1A and GlyT1B.

1 reference

12 December 2020

Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function

1 reference

12 December 2020

Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.

1 reference

12 December 2020

Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain

1 reference

12 December 2020

Glutamate-induced protease-mediated loss of plasma membrane Ca2+ pump activity in rat hippocampal neurons

1 reference

12 December 2020

Calpain and synaptic function

1 reference

12 December 2020

Oligomerization of KCC2 correlates with development of inhibitory neurotransmission.

1 reference

12 December 2020

Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity

1 reference

12 December 2020

Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation.

1 reference

12 December 2020

Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95.

1 reference

12 December 2020

The cellular, molecular and ionic basis of GABA(A) receptor signalling

1 reference

12 December 2020

Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes

1 reference

12 December 2020

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

1 reference

12 December 2020

KCC2 interacts with the dendritic cytoskeleton to promote spine development

1 reference

12 December 2020

Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase

1 reference

12 December 2020

Calpain in the CNS: from synaptic function to neurotoxicity

1 reference

12 December 2020

GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1.

1 reference

12 December 2020

Cation-chloride cotransporters and neuronal function

1 reference

12 December 2020

Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit

1 reference

12 December 2020

Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury

1 reference

12 December 2020

Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation

1 reference

12 December 2020

Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2.

1 reference

12 December 2020

Calpain inhibitors block long-term potentiation

1 reference

12 December 2020

A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus

1 reference

12 December 2020

Regulation of calpain-2 in neurons: implications for synaptic plasticity

1 reference

12 December 2020

Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.

1 reference

12 December 2020

Deconstruction for reconstruction: the role of proteolysis in neural plasticity and disease

1 reference

12 December 2020

Overexpression of μ-calpain in the anterior temporal neocortex of patients with intractable epilepsy correlates with clinicopathological characteristics

1 reference

12 December 2020

Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.

1 reference

12 December 2020

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

1 reference

12 December 2020

Cold-adapted protease enables quantitation of surface proteins in the absence of membrane trafficking

1 reference

12 December 2020

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

1 reference

12 December 2020

Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus

1 reference

12 December 2020

An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo

1 reference

12 December 2020

Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission

1 reference

12 December 2020

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

1 reference

12 December 2020

Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain

1 reference

12 December 2020

Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage

1 reference

12 December 2020

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1 reference

12 December 2020

Fodrin degradation by calcium-activated neutral proteinase (CANP) in retinal ganglion cell neurons and optic glia: preferential localization of CANP activities in neurons

1 reference

12 December 2020

Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices

1 reference

12 December 2020

Magnesium-free medium activates seizure-like events in the rat hippocampal slice

1 reference

12 December 2020

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1 reference

12 December 2020

The Biochemistry of Memory: A New and Specific Hypothesis

1 reference

12 December 2020

Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease

1 reference

12 December 2020

JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements

1 reference

12 December 2020

The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells

1 reference

12 December 2020

PEST sequences and regulation by proteolysis

1 reference

12 December 2020

Mechanisms of calpain proteolysis following traumatic brain injury: implications for pathology and therapy: implications for pathology and therapy: a review and update

1 reference

12 December 2020

Developmental changes in calpain activity, GluR1 receptors and in the effect of kainic acid treatment in rat brain

1 reference

12 December 2020

Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis

1 reference

12 December 2020

The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

1 reference

12 December 2020

10.1523/JNEUROSCI.6265-11.2012

Identifiers

DOI

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11 February 2020

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11 February 2020

PubMed publication ID

22895718

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895718%20AND%20SRC:MED&resulttype=core&format=json