PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation (Q42467584)

1 November 2017

title

PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation (English)

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chronic lymphocytic leukemia

1 November 2017

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Janet M D Plate

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1 November 2017

publication date

1 August 2004

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1 November 2017

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1 November 2017

volume

45

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1 November 2017

issue

8

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1 November 2017

page(s)

1519-1529

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Gene expression in chronic lymphocytic leukemia B cells and changes during induction of apoptosis

1 November 2017

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

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Cellular survival: a play in three Akts

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Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

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An induced proximity model for caspase-8 activation.

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Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation

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The triterpenoid CDDO induces apoptosis in refractory CLL B cells

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Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells

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Regulation of Akt/PKB activation by tyrosine phosphorylation

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Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

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The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes

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21 January 2018

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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

21 January 2018

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The protooncogene TCL1 is an Akt kinase coactivator

21 January 2018

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Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

21 January 2018

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Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

21 January 2018

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

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21 January 2018

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Akt is more than just a Bad kinase

21 January 2018

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10.1080/10428190410001683642

21 January 2018

Identifiers

DOI

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1 November 2017

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