Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice (Q42243192)

19 October 2017

Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice (English)

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19 October 2017

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Melanie Meyer-Luehmann

object named as

Melanie Meyer-Luehmann

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Monica Garcia-Alloza

object named as

Monica Garcia-Alloza

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David M. Holtzman

8

object named as

David M Holtzman

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19 October 2017

6

Bradley T Hyman

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19 October 2017

Jessica Koenigsknecht-Talboo

1

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19 October 2017

Maia Parsadanian

3

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19 October 2017

Mary Beth Finn

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19 October 2017

Brian J Bacskai

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19 October 2017

language of work or name

English

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publication date

1 December 2008

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19 October 2017

Journal of Neuroscience

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19 October 2017

28

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19 October 2017

52

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14156-14164

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describes a project that uses

19 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2743894/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

26 October 2017

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Active and passive immunotherapy for neurodegenerative disorders

26 October 2017

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Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

26 October 2017

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A limited role for microglia in antibody mediated plaque clearance in APP mice

26 October 2017

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Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

26 October 2017

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

26 October 2017

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Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

26 October 2017

1 reference

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

26 October 2017

1 reference

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Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

26 October 2017

1 reference

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

26 October 2017

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Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

26 October 2017

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Alzheimer's disease: genes, proteins, and therapy

26 October 2017

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Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

26 October 2017

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

26 October 2017

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Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

26 October 2017

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

26 October 2017

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Inflammation and Alzheimer's disease

26 October 2017

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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

26 October 2017

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

26 October 2017

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Cerebral amyloid angiopathy. A critical review

26 October 2017

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The incidence of cerebral amyloid angiopathy in Alzheimer's disease

26 October 2017

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Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

26 October 2017

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Congophilic angiopathy in the pathogenesis of Alzheimer's degeneration.

29 May 2018

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Immunotherapy reduces vascular amyloid-beta in PDAPP mice.

29 May 2018

1 reference

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Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice.

17 August 2018

1 reference

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Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

17 August 2018

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Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

17 August 2018

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Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging.

17 August 2018

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Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

17 August 2018

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Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

17 August 2018

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Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743894

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

17 August 2018

1 reference

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In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

17 August 2018

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Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

17 August 2018

1 reference

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In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories

17 August 2018

1 reference

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Cerebral hemorrhage after passive anti-Abeta immunotherapy

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743894

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743894

Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743894

Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743894

Histogenesis of demyelinating lesions in the spinal cord of guinea pigs with chronic relapsing experimental allergic encephalomyelitis

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19109498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Experimental allergic neuritis induced by galactocerebroside

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19109498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.4147-08.2008

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

19109498

1 reference