Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). (Q41988618)

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30 March 2020

title

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2) (English)

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polycystic kidney disease

30 March 2020

main subject

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13

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Ashley Pike

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Elisa Venturi

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Elisabeth P Carpenter

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Chitra A Shintre

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Annamaria Tessitore

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Leela Shrestha

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30 March 2020

Nicola A Burgess-Brown

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Nicola A Burgess-Brown

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30 March 2020

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Rebecca Sitsapesan

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Mariana Grieben

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Shubhashish M M Mukhopadhyay

30 March 2020

8

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Shubhashish Mukhopadhyay

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Rod Chalk

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30 March 2020

author name string

Sam El-Ajouz

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30 March 2020

Pravin Mahajan

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30 March 2020

language of work or name

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19 December 2016

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Nature Structural & Molecular Biology

30 March 2020

published in

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volume

24

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30 March 2020

issue

2

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30 March 2020

page(s)

114-122

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Polycystic kidney disease

30 March 2020

cites work

1 reference

Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group

31 March 2020

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The functions of TRPP2 in the vascular system

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Macrophages promote cyst growth in polycystic kidney disease

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

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Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

31 March 2020

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The ion channel polycystin-2 is required for left-right axis determination in mice

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Two populations of node monocilia initiate left-right asymmetry in the mouse

31 March 2020

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Association of PKD2 (polycystin 2) mutations with left-right laterality defects

31 March 2020

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The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

31 March 2020

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Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

31 March 2020

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

31 March 2020

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Bending the MDCK cell primary cilium increases intracellular calcium

31 March 2020

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Primary cilia are not calcium-responsive mechanosensors

31 March 2020

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Cell biology: Calcium contradictions in cilia.

31 March 2020

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Polycystin-2 is an intracellular calcium release channel

31 March 2020

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The versatile nature of the calcium-permeable cation channel TRPP2

31 March 2020

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An introduction to TRP channels

31 March 2020

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Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

31 March 2020

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Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity

31 March 2020

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Autosomal dominant polycystic kidney disease: the last 3 years

31 March 2020

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Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

31 March 2020

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Somatic inactivation of Pkd2 results in polycystic kidney disease

31 March 2020

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Multilocus polycystic disease

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A "two-hit" model of cystogenesis in autosomal dominant polycystic kidney disease?

31 March 2020

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The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.

31 March 2020

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Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

31 March 2020

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31 March 2020

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Structure of the TRPV1 ion channel determined by electron cryo-microscopy

31 March 2020

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Cryo-electron microscopy structure of the TRPV2 ion channel

31 March 2020

1 reference

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

31 March 2020

1 reference

Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects

31 March 2020

1 reference

N-glycosylation determines the abundance of the transient receptor potential channel TRPP2

31 March 2020

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Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2

31 March 2020

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31 March 2020

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Structure of the TRPA1 ion channel suggests regulatory mechanisms

31 March 2020

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31 March 2020

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Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

31 March 2020

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Crystal structure of the epithelial calcium channel TRPV6

31 March 2020

1 reference

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

31 March 2020

1 reference

The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function

31 March 2020

1 reference

Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2.

31 March 2020

1 reference

Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton

31 March 2020

1 reference

Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro

31 March 2020

1 reference

Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity

31 March 2020

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Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812.

31 March 2020

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dbSNP: the NCBI database of genetic variation

31 March 2020

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Altered trafficking and stability of polycystins underlie polycystic kidney disease

31 March 2020

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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

31 March 2020

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A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

31 March 2020

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TRPV1 structures in distinct conformations reveal activation mechanisms

31 March 2020

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Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

31 March 2020

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Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

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31 March 2020

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31 March 2020

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31 March 2020

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14 December 2024

https://opencitations.net/index/api/v1/citations/10.1017/S1431927614007995

Identifiers

DOI

10.1038/NSMB.3343

1 reference

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30 March 2020

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