Kinetic Isotope Effects for RNA Cleavage by 2′-O- Transphosphorylation: Nucleophilic Activation by Specific Base (Q41959334)

14 October 2017

Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base (English)

1 reference

14 October 2017

Kinetic Isotope Effects for RNA Cleavage by 2′-O- Transphosphorylation: Nucleophilic Activation by Specific Base (English)

1 reference

13 June 2024

6

Vernon E. Anderson

1 reference

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13 June 2024

author name string

Qing Dai

2

1 reference

14 October 2017

Hong Gu

3

1 reference

14 October 2017

Michael E. Harris

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20669950

13 June 2024

Daniel L. Kellerman

4

1 reference

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13 June 2024

Joseph A. Piccirilli

5

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13 June 2024

language of work or name

English

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publication date

1 August 2010

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14 October 2017

25 August 2010

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National Center for Biotechnology Information

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full work available at URL

13 June 2024

https://europepmc.org/articles/pmc2946848?pdf=render

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20669950/pdf/?tool=EBI

13 June 2024

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20669950/?tool=EBI

13 June 2024

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https://europepmc.org/articles/PMC2946848

13 June 2024

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https://europepmc.org/articles/PMC2946848?pdf=render

13 June 2024

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https://doi.org/10.1021/ja103550e

13 June 2024

online access status

open access

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https://pubs.acs.org/doi/pdf/10.1021/ja103550e

13 June 2024

1 reference

Journal of the American Chemical Society

13 June 2024

published in

1 reference

14 October 2017

132

1 reference

14 October 2017

33

1 reference

14 October 2017

11613-11621

1 reference

Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center

14 October 2017

1 reference

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Comparative enzymology and structural biology of RNA self-cleavage

5 June 2018

1 reference

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5 June 2018

1 reference

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Experimental analyses of the chemical dynamics of ribozyme catalysis

5 June 2018

1 reference

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The effects of sulfur substitution for the nucleophile and bridging oxygen atoms in reactions of hydroxyalkyl phosphate esters

5 June 2018

1 reference

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Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements

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1 reference

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Enzymatic mechanisms of phosphate and sulfate transfer.

5 June 2018

1 reference

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1 reference

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5 June 2018

1 reference

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Transition state differences in hydrolysis reactions of alkyl versus aryl phosphate monoester monoanions.

5 June 2018

1 reference

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5 June 2018

1 reference

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A common speed limit for RNA-cleaving ribozymes and deoxyribozymes

5 June 2018

1 reference

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5 June 2018

Ribozyme speed limits

1 reference

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Isotope effects in the study of phosphoryl and sulfuryl transfer reactions

5 June 2018

1 reference

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Isotope effects in the study of enzymatic phosphoryl transfer reactions

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

Hydrogen bonds and proton transfer in general-catalytic transition-state stabilization in enzyme catalysis.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

The enhancement of enzymatic rate accelerations by Brønsted acid-base catalysis

5 June 2018

1 reference

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Mechanisms of signaling and related enzymes

5 June 2018

1 reference

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Mechanisms of phosphoryl and acyl transfer

5 June 2018

1 reference

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Kinetics and mechanism in RNA cleavage

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

Use of isotope effects to elucidate enzyme mechanisms

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

On the interpretation of the observed linear free energy relationship in phosphate hydrolysis: a thorough computational study of phosphate diester hydrolysis in solution

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

Metal-catalyzed phosphodiester cleavage: secondary 18O isotope effects as an indicator of mechanism.

18 August 2018

1 reference

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Solvent deuterium isotope effects on phosphodiester cleavage catalyzed by an extraordinarily active Zn(II) complex

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center

18 August 2018

1 reference

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Analysis of solvent nucleophile isotope effects: evidence for concerted mechanisms and nucleophilic activation by metal coordination in nonenzymatic and ribozyme-catalyzed phosphodiester hydrolysis

18 August 2018

1 reference

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Compelling evidence for a stepwise mechanism of the alkaline cyclisation of uridine 3'-phosphate esters

18 August 2018

1 reference

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The ligand effect on the hydrolytic reactivity of Zn(II) complexes toward phosphate diesters

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

An altered mechanism of hydrolysis for a metal-complexed phosphate diester.

18 August 2018

1 reference

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Evidence for direct attack by hydroxide in phosphodiester hydrolysis

18 August 2018

1 reference

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Computational study of the influence of solvent on (16)O/(18)O equilibrium isotope effects in phosphate deprotonation reactions.

18 August 2018

1 reference

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Estimating pKa values for pentaoxyphosphoranes

18 August 2018

1 reference

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Theoretical evaluation of pK(a) in phosphoranes: implications for phosphate ester hydrolysis

18 August 2018

1 reference

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Proton inventory of the genomic HDV ribozyme in Mg(2+)-containing solutions.

18 August 2018

1 reference

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Parameters for the Description of Transition States

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946848

Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis

30 September 2018

1 reference

12 December 2020

The pKaof the Internucleotidic 2‘-Hydroxyl Group in Diribonucleoside (3‘→5‘) Monophosphates

1 reference

12 December 2020

Lanthanide Catalyzed Cyclization of Uridine 3'-p-Nitrophenyl Phosphate

1 reference

12 December 2020

Kinetics and Mechanisms for the Cleavage and Isomerization of the Phosphodiester Bonds of RNA by Brønsted Acids and Bases

1 reference

12 December 2020

Kinetic Isotope Effects and Stereochemical Studies on a Ribonuclease Model: Hydrolysis Reactions of Uridine 3'-Nitrophenyl Phosphate

1 reference

12 December 2020

Models of ribonuclease action. II. Specific acid, specific base, and neutral pathways for hydrolysis of a nucleotide diester analog

1 reference

12 December 2020

Pseudo-rotation in the hydrolysis of phosphate esters

3

1 reference

Kinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group

13 June 2024

19

1 reference

Canadian Journal of Chemistry

13 June 2024

57

77

967

Rishavy M. A.

1999

1 reference

A Correlation of Reaction Rates

13 June 2024

70

1 reference

13 June 2024

Identifiers

DOI

10.1021/JA103550E

1 reference

14 October 2017

1 reference

14 October 2017

1 reference