microtubule associated protein tau (Q419507)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10636

Microtubule associated protein, tubulin-binding repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

0 references

1 reference

13 November 2019

1 reference

13 November 2019

apolipoprotein binding

1 reference

1 January 2018

ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

SH3 domain binding

1 reference

1 January 2018

Tau interacts with src-family non-receptor tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

tubulin binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

protein binding

27 references

1 January 2018

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

LRRK2 Promotes Tau Accumulation, Aggregation and Release.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Tau promoter confers neuronal specificity and binds Sp1 and AP-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Akt and CHIP coregulate tau degradation through coordinated interactions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Impact of the cellular prion protein on amyloid-β and 3PO-tau processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

lipoprotein particle binding

1 reference

1 January 2018

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

enzyme binding

3 references

31 January 2017

A role for FKBP52 in Tau protein function

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

31 January 2017

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

31 January 2017

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

DNA binding

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

actin binding

3 references

1 January 2018

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

microtubule binding

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

3 references

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

31 January 2017

31 January 2017

Tau protein binds to microtubules through a flexible array of distributed weak sites

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

dynactin binding

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

receptor ligand activity

protein phosphatase 2A binding

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

Hsp90 protein binding

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

minor groove of adenine-thymine-rich DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

double-stranded DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

single-stranded DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

RNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

microtubule binding

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

8 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

1 January 2018

Tau protein binds to microtubules through a flexible array of distributed weak sites

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

enzyme binding

Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

A role for FKBP52 in Tau protein function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

protein-macromolecule adaptor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

phosphatidylinositol binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

identical protein binding

3 references

1 January 2018

LRRK2 Promotes Tau Accumulation, Aggregation and Release.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

protein homodimerization activity

1 reference

1 January 2018

Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

sequence-specific DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

receptor ligand activity

1 reference

1 January 2018

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

chaperone binding

1 reference

1 January 2018

Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

Hsp90 protein binding

1 reference

1 January 2018

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

histone-dependent DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

microtubule lateral binding

1 reference

1 January 2018

Surface-decoration of microtubules by human tau

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

phosphatidylinositol bisphosphate binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

1 reference

31 January 2017

cell body

1 reference

31 January 2017

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

nuclear periphery

1 reference

1 January 2018

Fluorescence microscopy and 3D image reconstruction of cytokine initiated disruption of the Parkinson disease associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

growth cone

1 reference

1 January 2018

Tau is enriched on dynamic microtubules in the distal region of growing axons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

neurofibrillary tangle

1 reference

31 January 2017

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

plasma membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

3 references

31 January 2017

31 January 2017

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

31 January 2017

tubulin complex

1 reference

1 January 2018

Tau is enriched on dynamic microtubules in the distal region of growing axons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

dendrite

1 reference

31 January 2017

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

cytoplasmic ribonucleoprotein granule

1 reference

1 January 2018

The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

nucleus

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

cytosol

microtubule associated complex

3 references

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

1 reference

31 January 2017

nuclear speck

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

axon

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

3 references

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

31 January 2017

31 January 2017

Tau is enriched on dynamic microtubules in the distal region of growing axons

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

somatodendritic compartment

1 reference

31 January 2017

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

soma

1 reference

1 January 2018

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

axon cytoplasm

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

extracellular region

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

5 references

1 January 2018

1 January 2018

LRRK2 Promotes Tau Accumulation, Aggregation and Release.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

1 January 2018

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

mitochondrion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

4 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

1 January 2018

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

plasma membrane

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

1 January 2018

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

1 January 2018

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

microtubule cytoskeleton

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Surface-decoration of microtubules by human tau

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

axon

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

1 January 2018

Tau is enriched on dynamic microtubules in the distal region of growing axons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

dendrite

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

3 references

1 January 2018

1 January 2018

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

axolemma

1 reference

1 January 2018

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

neuron projection

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

dendritic spine

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

main axon

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

membrane raft

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

glial cell projection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

neurofibrillary tangle

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

biological process

generation of neurons

1 reference

1 January 2018

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of autophagy

IGI

1 reference

1 January 2018

Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of microtubule polymerization

IGI

1 reference

31 January 2017

A protein factor essential for microtubule assembly

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

positive regulation of microtubule polymerization

2 references

1 January 2018

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

positive regulation of axon extension

1 reference

1 January 2018

Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

microtubule cytoskeleton organization

1 reference

31 January 2017

A protein factor essential for microtubule assembly

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

microglial cell activation

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

signal transduction

1 reference

31 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

memory

1 reference

1 January 2018

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

negative regulation of mitochondrial membrane potential

1 reference

1 January 2018

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

axonal transport of mitochondrion

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cytoplasmic microtubule organization

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

neuron projection development

1 reference

31 January 2017

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

positive regulation of superoxide anion generation

1 reference

1 January 2018

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

negative regulation of kinase activity

1 reference

1 January 2018

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cellular response to heat

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

astrocyte activation

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

intracellular distribution of mitochondria

1 reference

1 January 2018

Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

synapse organization

1 reference

1 January 2018

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of calcium-mediated signaling

1 reference

1 January 2018

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

protein complex oligomerization

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

plus-end-directed organelle transport along microtubule

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of mitochondrial fission

IC

1 reference

1 January 2018

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

negative regulation of mitochondrial fission

IC

1 reference

1 January 2018

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

axonal transport

1 reference

31 January 2017

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10636

regulation of cellular response to heat

1 reference

1 January 2018

Nuclear tau, a key player in neuronal DNA protection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

positive regulation of neuron death

1 reference

1 January 2018

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

positive regulation of protein localization to synapse

1 reference

1 January 2018

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

neurofibrillary tangle assembly

1 reference

1 January 2018

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

negative regulation of establishment of protein localization to mitochondrion

1 reference

1 January 2018

Tau promotes neurodegeneration via DRP1 mislocalization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

positive regulation of diacylglycerol kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of response to DNA damage stimulus

1 reference

1 January 2018

Nuclear tau, a key player in neuronal DNA protection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

microtubule cytoskeleton organization

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

A protein factor essential for microtubule assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

internal protein amino acid acetylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cell-cell signaling

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

response to lead ion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 reference

1 January 2018

regulation of signaling receptor activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

negative regulation of gene expression

1 reference

1 January 2018

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

rRNA metabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

central nervous system neuron development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of microtubule polymerization or depolymerization

1 reference

1 January 2018

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of microtubule polymerization

Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

A protein factor essential for microtubule assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

neuron projection development

regulation of chromosome organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

stress granule assembly

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cellular response to reactive oxygen species

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

microtubule polymerization

1 reference

1 January 2018

Regulation of Microtubule Assembly by Tau and not by Pin1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

regulation of synaptic plasticity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

axon development

1 reference

1 January 2018

Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

supramolecular fiber organization

2 references

1 January 2018

Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

1 January 2018

Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

axonal transport

regulation of long-term synaptic depression

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

positive regulation of protein localization

1 reference

1 January 2018

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

amyloid fibril formation

1 reference

1 January 2018

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cellular response to nerve growth factor stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

cellular response to brain-derived neurotrophic factor stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10636&geneProductId=UniProtKB:P10636

http://purl.uniprot.org/uniprot/P10636

Gene Atlas image

PBB GE MAPT 203929 s at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Microtubule associated protein, tubulin-binding repeat

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10636

Identifiers

MeSH descriptor ID

D016875

subject named as

tau Proteins

0 references

MeSH tree code

D12.776.220.600.450.510

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1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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27 December 2019

1 reference

27 December 2019

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27 December 2019

1 reference

27 December 2019

1 reference

13 November 2019

Encyclopædia Britannica Online ID

topic/Tau-protein

subject named as

tau protein

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28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023

YSO-Wikidata mapping project

25 May 2023

WikiSkripta article ID

0 references

1 reference