CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation (Q41825679)

12 October 2017

CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation (English)

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12 October 2017

8

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12 October 2017

Catrin A Pritchard

9

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author name string

Catherine Noble

1

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12 October 2017

Kathryn Mercer

2

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12 October 2017

Jahan Hussain

3

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12 October 2017

Linda Carragher

4

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12 October 2017

Susan Giblett

5

1 reference

12 October 2017

Robert Hayward

6

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12 October 2017

Cam Patterson

7

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12 October 2017

1 September 2008

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12 October 2017

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12 October 2017

31

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12 October 2017

6

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12 October 2017

862-872

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describes a project that uses

12 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2640467/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

6 June 2018

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CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation

6 June 2018

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Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

6 June 2018

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Regulation and role of Raf-1/B-Raf heterodimerization

6 June 2018

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The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

6 June 2018

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Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling

6 June 2018

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Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

6 June 2018

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Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

6 June 2018

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

6 June 2018

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The RAF proteins take centre stage

6 June 2018

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Guilty as charged: B-RAF is a human oncogene

6 June 2018

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

6 June 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

6 June 2018

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Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites

6 June 2018

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Raf proteins and cancer: B-Raf is identified as a mutational target

6 June 2018

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Cell adhesion protects c-Raf-1 against ubiquitin-dependent degradation by the proteasome

6 June 2018

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Mutations of the BRAF gene in human cancer

6 June 2018

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Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

6 June 2018

1 reference

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Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

6 June 2018

1 reference

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Positive and negative regulation of Raf kinase activity and function by phosphorylation

6 June 2018

1 reference

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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

6 June 2018

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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

6 June 2018

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MEK kinase activity is not necessary for Raf-1 function

6 June 2018

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Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade

6 June 2018

1 reference

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Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

6 June 2018

1 reference

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

6 June 2018

1 reference

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

6 June 2018

1 reference

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Expression of the A-raf proto-oncogene in the normal adult and embryonic mouse.

6 June 2018

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

6 June 2018

1 reference

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14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity

6 June 2018

1 reference

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Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome

6 June 2018

1 reference

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Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase

6 June 2018

1 reference

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

6 June 2018

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Control of the ERK MAP kinase cascade by Ras and Raf.

6 June 2018

1 reference

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Negative regulation of Raf-1 by phosphorylation of serine 621.

6 June 2018

1 reference

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PEST sequences and regulation by proteolysis

6 June 2018

1 reference

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

Identification of the major phosphorylation sites of the Raf-1 kinase.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

Activation of Raf as a result of recruitment to the plasma membrane

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

Methylglyoxal downregulates Raf-1 protein through a ubiquitination-mediated mechanism

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2640467

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18922468

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2008.08.026

1 reference

12 October 2017

1 reference

12 October 2017

PubMed publication ID

18922468

1 reference