Active nuclear import and cytoplasmic retention of activation-induced deaminase (Q41792388)

10 October 2017

title

Active nuclear import and cytoplasmic retention of activation-induced deaminase (English)

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Activation induced cytidine deaminase

10 October 2017

main subject

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identical protein binding

GOA release 2020-03-11

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GOA release 2020-03-11

author

Alejandro Buschiazzo

6

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10 October 2017

Javier M Di Noia

7

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author name string

Anne-Marie Patenaude

1

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10 October 2017

Alexandre Orthwein

2

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10 October 2017

Yi Hu

3

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10 October 2017

Vanina A Campo

4

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10 October 2017

Bodil Kavli

5

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10 October 2017

publication date

3 May 2009

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Nature Structural & Molecular Biology

10 October 2017

published in

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10 October 2017

volume

16

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10 October 2017

issue

5

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10 October 2017

page(s)

517-527

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

10 October 2017

cites work

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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The biochemistry of somatic hypermutation

21 January 2018

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Molecular mechanisms of antibody somatic hypermutation.

21 January 2018

1 reference

Somatic hypermutation of the AID transgene in B and non-B cells

21 January 2018

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Constitutive expression of AID leads to tumorigenesis

21 January 2018

1 reference

Two levels of protection for the B cell genome during somatic hypermutation.

21 January 2018

1 reference

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

1 reference

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

1 reference

AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

1 reference

Regulation of AID expression in the immune response

21 January 2018

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miR-181b negatively regulates activation-induced cytidine deaminase in B cells

21 January 2018

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MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation

21 January 2018

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MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase

21 January 2018

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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

21 January 2018

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Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

21 January 2018

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Proteasomal degradation restricts the nuclear lifespan of AID

21 January 2018

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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

21 January 2018

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Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation

21 January 2018

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PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells

21 January 2018

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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

21 January 2018

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Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

21 January 2018

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Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation

21 January 2018

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AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.

21 January 2018

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Transport into and out of the nucleus

21 January 2018

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Transport between the cell nucleus and the cytoplasm

21 January 2018

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Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

21 January 2018

1 reference

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

21 January 2018

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The APOBEC-2 crystal structure and functional implications for the deaminase AID

21 January 2018

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Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues

21 January 2018

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Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

21 January 2018

1 reference

Classical nuclear localization signals: definition, function, and interaction with importin alpha

21 January 2018

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Cellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import block

21 January 2018

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Multiple mechanisms promote the inhibition of classical nuclear import upon exposure to severe oxidative stress

21 January 2018

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Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants

21 January 2018

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The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

21 January 2018

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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

21 January 2018

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AID mutant analyses indicate requirement for class-switch-specific cofactors

21 January 2018

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Separate domains of AID are required for somatic hypermutation and class-switch recombination

21 January 2018

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Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins

21 January 2018

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The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay

21 January 2018

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Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing

21 January 2018

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AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

1 reference

Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix

21 January 2018

1 reference

Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding.

21 January 2018

1 reference

Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene

21 January 2018

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Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization

21 January 2018

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The double-edged sword of activation-induced cytidine deaminase.

21 January 2018

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Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

21 January 2018

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Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma.

21 January 2018

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Expression of the AID protein in normal and neoplastic B cells

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

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Dependence of antibody gene diversification on uracil excision.

21 January 2018

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Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line

21 January 2018

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Evolution of the immunoglobulin heavy chain class switch recombination mechanism

21 January 2018

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A role for AID in chromosome translocations between c-myc and the IgH variable region.

31 March 2020

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Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

31 March 2020

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Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

31 March 2020

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Nucleocytoplasmic shuttling of the progesterone receptor

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19412186

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1598

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10 October 2017

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