Microtubules and actin filaments: dynamic targets for cancer chemotherapy (Q41713562)

7 October 2017

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title

Microtubules and actin filaments: dynamic targets for cancer chemotherapy (English)

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7 October 2017

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M. A. Jordan

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9484604

10 December 2024

L. Wilson

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9484604

10 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9484604

10 December 2024

publication date

1 February 1998

1 reference

7 October 2017

February 1998

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9484604

full work available at URL

10 December 2024

https://api.elsevier.com/content/article/PII:S0955067498800951?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/S0955-0674(98)80095-1

https://api.elsevier.com/content/article/PII:S0955067498800951?httpAccept=text/plain

10 December 2024

1 reference

https://api.crossref.org/works/10.1016/S0955-0674(98)80095-1

Current Opinion in Cell Biology

10 December 2024

published in

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7 October 2017

volume

10

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7 October 2017

issue

1

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7 October 2017

page(s)

123-130

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Dynamic instability of microtubule growth

7 October 2017

cites work

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7 January 2021

Opposite end assembly and disassembly of microtubules at steady state in vitro

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7 January 2021

Microtubule treadmills--possible molecular machinery

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7 January 2021

Microtubule treadmilling in vivo

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7 January 2021

Microtubule dynamics: treadmilling comes around again

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7 January 2021

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling

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7 January 2021

Actin microfilament dynamics in locomoting cells

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7 January 2021

Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: direct visualization in live newt lung cells

1 reference

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7 January 2021

Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells

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7 January 2021

Microtubule dynamics: taking aim at a moving target

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7 January 2021

Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton.

1 reference

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7 January 2021

Taxol stabilizes microtubules in mouse fibroblast cells

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7 January 2021

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

1 reference

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7 January 2021

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

1 reference

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7 January 2021

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

1 reference

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7 January 2021

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

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7 January 2021

Vinblastine suppresses dynamics of individual microtubules in living interphase cells

1 reference

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7 January 2021

Differential effects of vinblastine on polymerization and dynamics at opposite microtubule ends

1 reference

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7 January 2021

Kinetic Stabilization of Microtubule Dynamics at Steady State in Vitro by Substoichiometric Concentrations of Tubulin-Colchicine Complex

1 reference

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7 January 2021

Mechanism of Action of the Unusually Potent Microtubule Inhibitor Cryptophycin 1

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7 January 2021

Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

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7 January 2021

Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: A possible mechanistic basis for its antitumor action

1 reference

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7 January 2021

Substoichiometric binding of taxol suppresses microtubule dynamics.

1 reference

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7 January 2021

Chromosomes initiate spindle assembly upon experimental dissolution of the nuclear envelope in grasshopper spermatocytes

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7 January 2021

Abnormal centrosome amplification in the absence of p53.

1 reference

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7 January 2021

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work

1 reference

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7 January 2021

Mitotic forces control a cell-cycle checkpoint

1 reference

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7 January 2021

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint

1 reference

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7 January 2021

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

1 reference

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7 January 2021

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

1 reference

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7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

1 reference

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7 January 2021

Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast

1 reference

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7 January 2021

GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion

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7 January 2021

The spindle assembly checkpoint

1 reference

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7 January 2021

Kinetochore fiber maturation in PtK1 cells and its implications for the mechanisms of chromosome congression and anaphase onset

1 reference

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7 January 2021

Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.

1 reference

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7 January 2021

Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells

1 reference

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7 January 2021

Suppression of microtubule dynamics by LY290181. A potential mechanism for its antiproliferative action.

1 reference

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7 January 2021

Inhibition of Mitosis and Microtubule Function through Direct Tubulin Binding by a Novel Antiproliferative Naphthopyran LY290181

1 reference

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7 January 2021

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1 reference

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7 January 2021

Interaction of cryptophycin 1 with tubulin and microtubules

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7 January 2021

In vitro synergy of paclitaxel (Taxol) and vinorelbine (navelbine) against human melanoma cell lines

1 reference

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7 January 2021

Simultaneous combination of microtubule depolymerizing and stabilizing agents acts at low doses

1 reference

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7 January 2021

Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.

1 reference

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7 January 2021

Interaction of estramustine with tubulin isotypes

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7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

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7 January 2021

The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation

1 reference

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7 January 2021

Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules

1 reference

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7 January 2021

Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18

1 reference

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7 January 2021

Medical aspects of the actin cytoskeleton

1 reference

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7 January 2021

Signal transduction and actin filament organization

1 reference

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7 January 2021

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1 reference

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7 January 2021

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

1 reference

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7 January 2021

Altered actin polymerization dynamics in various malignant cell types: evidence for differential sensitivity to cytochalasin B

1 reference

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7 January 2021

Effects of cytochalasin and phalloidin on actin

1 reference

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7 January 2021

Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D.

1 reference

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7 January 2021

High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A.

1 reference

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7 January 2021

Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton.

1 reference

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7 January 2021

Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments

1 reference

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7 January 2021

Misakinolide A is a marine macrolide that caps but does not sever filamentous actin

1 reference

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7 January 2021

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

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7 January 2021

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

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7 January 2021

Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue

14

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Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis

10 December 2024

29

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Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle

10 December 2024

42

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Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells

10 December 2024

44

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Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells

10 December 2024

46

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Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

10 December 2024

49

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Bcl2 is the guardian of microtubule integrity

10 December 2024

51

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Microtubule effects of welwistatin, a cyanobacterial indolinone that circumvents multiple drug resistance

10 December 2024

55

1 reference

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Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines

10 December 2024

64

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Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

10 December 2024

67

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G-actin as a risk factor and modulatable endpoint for cancer chemoprevention trials

10 December 2024

82

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Widespread loss of gelsolin in breast cancers of humans, mice, and rats

10 December 2024

83

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10 December 2024

Identifiers

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7 October 2017

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