Recent advances in understanding V(D)J recombination. (Q41430421)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9100979%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

review article

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title

Recent advances in understanding V(D)J recombination (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9100979%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

Gellert M

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9100979%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

publication date

1 January 1997

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9100979%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

published in

Advances in Immunology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9100979%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

volume

64

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2 November 2019

page(s)

39-64

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scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

2 November 2019

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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

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p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

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A severe combined immunodeficiency mutation in the mouse

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scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase

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Coding sequence composition flanking either signal element alters V(D)J recombination efficiency

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7 January 2021

Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion

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Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1

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An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement

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The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

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RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1

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The mechanism of conservative site-specific recombination

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7 January 2021

Analysis of regions of RAG-2 important for V(D)J recombination

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Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein

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DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

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Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents

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Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

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7 January 2021

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

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7 January 2021

HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

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Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

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7 January 2021

Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination

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7 January 2021

Regulation of RAG-2 protein expression in avian thymocytes

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7 January 2021

The scid mutation in mice causes a general defect in DNA repair

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7 January 2021

Molecular analysis of V(D)J recombination

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7 January 2021

Coding end sequence can markedly affect the initiation of V(D)J recombination

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7 January 2021

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

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7 January 2021

Nucleocytoplasmic transport

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7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

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7 January 2021

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

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7 January 2021

The recombination activating gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic analysis

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7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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7 January 2021

A link between double-strand break-related repair and V(D)J recombination: the scid mutation

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7 January 2021

V(D)J recombination: a functional definition of the joining signals

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7 January 2021

Hairpin formation in the self-complementary dodecamer d-GGTACGCGTACC and derivatives containing GA and IA mispairs

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7 January 2021

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

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7 January 2021

Hairpin opening by single-strand-specific nucleases

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7 January 2021

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes

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7 January 2021

Regions of RAG1 protein critical for V(D)J recombination

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7 January 2021

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

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Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

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7 January 2021

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

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7 January 2021

Rearrangement by inversion of a T-cell receptor delta variable region gene located 3' of the delta constant region gene

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7 January 2021

Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

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7 January 2021

DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes

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7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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7 January 2021

P nucleotide insertions and the resolution of hairpin DNA structures in mammalian cells

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7 January 2021

Novel strand exchanges in V(D)J recombination

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7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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7 January 2021

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints

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7 January 2021

Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation

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7 January 2021

V(D)J recombination and the cell cycle.

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7 January 2021

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

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7 January 2021

Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements

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7 January 2021

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

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7 January 2021

Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments

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7 January 2021

V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP

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7 January 2021

Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism

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7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

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7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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7 January 2021

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

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7 January 2021

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells

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7 January 2021

Formation and resolution of double-strand break intermediates in V(D)J rearrangement

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7 January 2021

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks

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7 January 2021

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.

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7 January 2021

Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition

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7 January 2021

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

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7 January 2021

Characterization of broken DNA molecules associated with V(D)J recombination

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7 January 2021

RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

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7 January 2021

Expression and V(D)J recombination activity of mutated RAG-1 proteins

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7 January 2021

Definition of a core region of RAG-2 that is functional in V(D)J recombination

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7 January 2021

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

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7 January 2021

V(D)J recombination: molecular biology and regulation

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7 January 2021

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

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7 January 2021

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination

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7 January 2021

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

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7 January 2021

Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.

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7 January 2021

scid cells efficiently integrate hairpin and linear DNA substrates

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7 January 2021

The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

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7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

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Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

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7 January 2021

RAG-2 expression is not essential for chicken immunoglobulin gene conversion

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7 January 2021

New insights into V(D)J recombination and its role in the evolution of the immune system

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7 January 2021

Base-pairing shift in the major groove of (CA)n tracts by B-DNA crystal structures

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7 January 2021

Somatic generation of antibody diversity

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7 January 2021

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

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7 January 2021

Initiation of V(D)J recombination in a cell-free system.

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7 January 2021

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7 January 2021

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

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7 January 2021

Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNa termini mediated by the viral integrase protein

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7 January 2021

What to do at an end: DNA double-strand-break repair

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7 January 2021

Megabase inversions in the human genome as physiological events

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7 January 2021

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

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7 January 2021

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

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7 January 2021

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