Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts (Q41399533)

30 September 2017

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title

Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts (English)

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30 September 2017

author

Cristina Maria Kokron

1

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30 September 2017

Bonilla FA

2

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30 September 2017

Oettgen HC

3

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30 September 2017

Ramesh N

4

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30 September 2017

Geha RS

5

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30 September 2017

Pandolfi F

6

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30 September 2017

publication date

1 March 1997

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Journal of Clinical Immunology

30 September 2017

published in

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30 September 2017

volume

17

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30 September 2017

issue

2

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30 September 2017

page(s)

109-126

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Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice

30 September 2017

cites work

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12 December 2020

Two genetically separable steps in the differentiation of thymic epithelium.

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12 December 2020

Constitutive activation of Src family kinases in mouse embryos that lack Csk.

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12 December 2020

Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice

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12 December 2020

Profound block in thymocyte development in mice lacking p56lck

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12 December 2020

Peripheral lymphoid development and function in TCR mutant mice

1 reference

12 December 2020

Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.

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12 December 2020

Immune responses in interleukin-2-deficient mice

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12 December 2020

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

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12 December 2020

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

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12 December 2020

Failure of B-cell differentiation in mice lacking the transcription factor EBF.

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12 December 2020

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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12 December 2020

An HMG-box-containing T-cell factor required for thymocyte differentiation.

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12 December 2020

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM

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12 December 2020

Negative feedback regulation of IgE synthesis by murine CD23.

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12 December 2020

Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase

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12 December 2020

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

1 reference

12 December 2020

IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide.

1 reference

12 December 2020

IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

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12 December 2020

Immunological studies of NK cell-deficient beige mice. II. Analysis of T-lymphocyte functions in beige mice.

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12 December 2020

Bone and haematopoietic defects in mice lacking c-fos

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12 December 2020

Impaired antibody response of C57BL/6 beige mutant mice to a thymus-independent type 2 antigen

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12 December 2020

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

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12 December 2020

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

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12 December 2020

Differential requirements of CD45 for lymphocyte development and function

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12 December 2020

Immunodeficiency in protein kinase cbeta-deficient mice

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12 December 2020

Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

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12 December 2020

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

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12 December 2020

Gene targeting yields a CD18-mutant mouse for study of inflammation.

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12 December 2020

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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12 December 2020

Interleukin-10-deficient mice develop chronic enterocolitis

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12 December 2020

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice

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12 December 2020

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog

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12 December 2020

Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

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12 December 2020

Tumor induction and tissue atrophy in mice lacking E2F-1

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12 December 2020

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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12 December 2020

Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

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12 December 2020

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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12 December 2020

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

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12 December 2020

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

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12 December 2020

T cell development in mice lacking the CD3-zeta/eta gene.

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12 December 2020

CD8 is needed for development of cytotoxic T cells but not helper T cells

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12 December 2020

Essential role of Stat6 in IL-4 signalling

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12 December 2020

An early haematopoietic defect in mice lacking the transcription factor GATA-2

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12 December 2020

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

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12 December 2020

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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12 December 2020

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

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12 December 2020

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

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12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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12 December 2020

Immune function in mice lacking the perforin gene

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12 December 2020

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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12 December 2020

Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice

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12 December 2020

Syk tyrosine kinase required for mouse viability and B-cell development

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12 December 2020

An enhanced immune response in mice lacking the transcription factor NFAT1.

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12 December 2020

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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12 December 2020

Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: experiments of nature continue to point the way.

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12 December 2020

Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice

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12 December 2020

Regulation of the B cell response to T-dependent antigens by classical pathway complement

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12 December 2020

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

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12 December 2020

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene

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12 December 2020

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology

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12 December 2020

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

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12 December 2020

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

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12 December 2020

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness

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12 December 2020

A critical role of λ5 protein in B cell development

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12 December 2020

Lymphocyte ontogeny and activation in gene targeted mutant mice

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12 December 2020

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon

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12 December 2020

Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins.

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12 December 2020

Defective activation and survival of T cells lacking the Ets-1 transcription factor

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12 December 2020

Shutdown of class switch recombination by deletion of a switch region control element.

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12 December 2020

Generation and analysis of interleukin-4 deficient mice

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12 December 2020

Negative regulation of T-cell adhesion and activation by CD43

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12 December 2020

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

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12 December 2020

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

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12 December 2020

Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse

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12 December 2020

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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12 December 2020

Altering the genome by homologous recombination

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12 December 2020

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

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12 December 2020

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

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12 December 2020

Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia.

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12 December 2020

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

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12 December 2020

Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response

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12 December 2020

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

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12 December 2020

Independent modes of natural killing distinguished in mice lacking Lag3

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12 December 2020

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

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12 December 2020

Primary immunodeficiency diseases. Report of a WHO Scientific Group

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12 December 2020

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

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12 December 2020

Lack of mature B cells in nude mice with X-linked immune deficiency

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12 December 2020

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

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12 December 2020

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12 December 2020

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

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12 December 2020

Early arrest of B cell development in nude, X-linked immune-deficient mice

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12 December 2020

RAG mutations in human B cell-negative SCID.

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12 December 2020

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells

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12 December 2020

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

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12 December 2020

Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice

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12 December 2020

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

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12 December 2020

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

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12 December 2020

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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12 December 2020

Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency

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12 December 2020

Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

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12 December 2020

Mice deficient for the CD40 ligand

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12 December 2020

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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12 December 2020

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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12 December 2020

Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency

1 reference

12 December 2020

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

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12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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12 December 2020

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

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12 December 2020

Impaired mucosal immune responses in interleukin 4-targeted mice

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12 December 2020

Essential role for ZAP-70 in both positive and negative selection of thymocytes

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12 December 2020

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

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12 December 2020

Recurrent bacterial infections and dysgamma-globulinemia: deficiency of 7S gamma-globulins in the presence of elevated 19S gamma-globulins. Report of two cases

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12 December 2020

Genotyping with DNA probes in combined immunodeficiency syndrome with defective expression of HLA.

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12 December 2020

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

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12 December 2020

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

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12 December 2020

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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12 December 2020

Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival

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12 December 2020

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

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12 December 2020

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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12 December 2020

Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity

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12 December 2020

Impaired expansion of mouse B cell progenitors lacking Btk.

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12 December 2020

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

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12 December 2020

The CBA/N mouse strain: an experimental model illustrating the influence of the X-chromosome on immunity.

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12 December 2020

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

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12 December 2020

Defective lymphoid development in mice lacking Jak3

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12 December 2020

Development and function of T cells in mice with a disrupted CD2 gene

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12 December 2020

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

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12 December 2020

The helix-loop-helix gene E2A is required for B cell formation

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12 December 2020

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

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12 December 2020

Mice lacking MHC class II molecules

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12 December 2020

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

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12 December 2020

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

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12 December 2020

Mice lacking the MHC class II-associated invariant chain

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12 December 2020

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

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12 December 2020

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

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12 December 2020

Knockout mice: how to make them and why. The immunological approach

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12 December 2020

MHC class II-deficient combined immunodeficiency: a disease of gene regulation

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12 December 2020

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

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12 December 2020

Differential T cell costimulatory requirements in CD28-deficient mice

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12 December 2020

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

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12 December 2020

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

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12 December 2020

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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12 December 2020

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

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12 December 2020

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

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12 December 2020

FcR gamma chain deletion results in pleiotrophic effector cell defects

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12 December 2020

X-linked severe combined immunodeficiency. Diagnosis in males with sporadic severe combined immunodeficiency and clarification of clinical findings

1 reference

12 December 2020

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

1 reference

12 December 2020

Major histocompatibility complex class II deficiency: clinical manifestations, immunologic features, and outcome

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12 December 2020

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

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12 December 2020

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

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12 December 2020

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

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12 December 2020

Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins

1 reference

12 December 2020

Neurogenic amplification of immune complex inflammation

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12 December 2020

Phenotype and function of CD4+ T cells in mice lacking invariant chain

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12 December 2020

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells

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12 December 2020

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

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12 December 2020

The C5a chemoattractant receptor mediates mucosal defence to infection

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12 December 2020

Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in fas-deficient mice

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12 December 2020

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

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12 December 2020

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

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12 December 2020

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1 reference

12 December 2020

Knockouts. Targeting the mouse genome: a compendium of knockouts (Part I)

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12 December 2020

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

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12 December 2020

Altered peptidase and viral-specific T cell response in LMP2 mutant mice.

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12 December 2020

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

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12 December 2020

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

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12 December 2020

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

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12 December 2020

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

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12 December 2020

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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12 December 2020

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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12 December 2020

Active anaphylaxis in IgE-deficient mice

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12 December 2020

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

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12 December 2020

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

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12 December 2020

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

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12 December 2020

Immune response in mice that lack the interferon-gamma receptor

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12 December 2020

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

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12 December 2020

Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells

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12 December 2020

Leukocyte adhesion deficiency: molecular basis and functional consequences

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12 December 2020

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

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12 December 2020

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

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12 December 2020

T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice

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12 December 2020

Lymphocyte populations and immune responses in CD5-deficient mice

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12 December 2020

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

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12 December 2020

Identification of the homologous beige and Chediak-Higashi syndrome genes

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12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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12 December 2020

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

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12 December 2020

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

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12 December 2020

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene

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12 December 2020

Production of homozygous mutant ES cells with a single targeting construct

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12 December 2020

Defective B cell development and function in Btk-deficient mice

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12 December 2020

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression

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12 December 2020

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

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12 December 2020

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

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12 December 2020

MHC class I expression in mice lacking the proteasome subunit LMP-7

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12 December 2020

The Primary Immunodeficiencies

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12 December 2020

Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand

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12 December 2020

Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal

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12 December 2020

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

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12 December 2020

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

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12 December 2020

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

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12 December 2020

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

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12 December 2020

Atm-deficient mice: a paradigm of ataxia telangiectasia

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12 December 2020

RAG-1-deficient mice have no mature B and T lymphocytes

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12 December 2020

Role of TCR zeta chain in T cell development and selection

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12 December 2020

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

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12 December 2020

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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12 December 2020

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

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12 December 2020

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain

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12 December 2020

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

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12 December 2020

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

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12 December 2020

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

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12 December 2020

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

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12 December 2020

The nude mouse: a model of deficient T-cell function

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12 December 2020

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

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12 December 2020

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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12 December 2020

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity

1 reference

12 December 2020

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

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12 December 2020

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

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12 December 2020

Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens

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12 December 2020

Homozygous human TAP peptide transporter mutation in HLA class I deficiency

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12 December 2020

Adenosine deaminase deficiency

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12 December 2020

Growth and differentiation of embryonic stem cells that lack an intact c-fos gene

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12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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12 December 2020

Immunodeficiency with hyper-IgM (HIM)

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12 December 2020

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression

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12 December 2020

Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

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12 December 2020

Allo-skin graft rejection, tumor rejection and natural killer activity in mice lacking p56lck

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12 December 2020

Adenosine–deaminase–deficient mice die perinatally and exhibit liver–cell degeneration, atelectasis and small intestinal cell death

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12 December 2020

Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication

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12 December 2020

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

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12 December 2020

Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells

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12 December 2020

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

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12 December 2020

The Ikaros gene is required for the development of all lymphoid lineages

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12 December 2020

Efficient immune responses in mice lacking N-region diversity

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12 December 2020

Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness

1 reference

12 December 2020

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1027322314256

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Dimensions Publication ID

30 September 2017

1039128747

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