AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. (Q41071776)

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8 November 2019

title

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor (English)

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8 November 2019

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2

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8 November 2019

José A. Esté

4

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8 November 2019

Thomas P Sakmar

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8 November 2019

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E De Clercq

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8 November 2019

author name string

G A Donzella

1

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8 November 2019

S W Lin

3

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8 November 2019

K A Nagashima

5

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8 November 2019

P J Maddon

6

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8 November 2019

G P Allaway

7

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8 November 2019

G Henson

9

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8 November 2019

J P Moore

11

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8 November 2019

language of work or name

English

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publication date

1 January 1998

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8 November 2019

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8 November 2019

volume

4

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8 November 2019

issue

1

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page(s)

72-77

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

8 November 2019

cites work

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The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

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The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

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The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression

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Genotypic and phenotypic characterization of HIV-1 patients with primary infection

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7 January 2021

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

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7 January 2021

Identification of a major co-receptor for primary isolates of HIV-1

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7 January 2021

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

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A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

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7 January 2021

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

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7 January 2021

Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry

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7 January 2021

Change in coreceptor use correlates with disease progression in HIV-1--infected individuals

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7 January 2021

HIV blocked by chemokine antagonist

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7 January 2021

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

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7 January 2021

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event

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7 January 2021

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

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7 January 2021

The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication

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7 January 2021

The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding

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7 January 2021

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4

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7 January 2021

Dissociation between syncytia formation and HIV spreading. Suppression of syncytia formation does not necessarily reflect inhibition of HIV infection

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7 January 2021

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

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7 January 2021

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

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7 January 2021

CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.

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7 January 2021

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

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7 January 2021

Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines

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7 January 2021

CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons

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7 January 2021

Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry

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7 January 2021

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

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7 January 2021

The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation

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7 January 2021

Selectivity and antagonism of chemokine receptors

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7 January 2021

Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry

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7 January 2021

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

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7 January 2021

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

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7 January 2021

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

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7 January 2021

Small amino acid sequence changes within the V2 domain can affect the function of a T-cell line-tropic human immunodeficiency virus type 1 envelope gp120.

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7 January 2021

Identifiers

DOI

10.1038/NM0198-072

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9427609%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference