Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300. (Q41059110)

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9 November 2019

title

Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300 (English)

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9 November 2019

1

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9 November 2019

author name string

F DeWitte

series ordinal

2

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9 November 2019

D W Hum

series ordinal

3

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language of work or name

English

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publication date

1 February 1998

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Journal of Biological Chemistry

9 November 2019

published in

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9 November 2019

volume

273

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9 November 2019

issue

8

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9 November 2019

page(s)

4585-4591

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Molecular biology of steroid hormone synthesis

9 November 2019

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Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta

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Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements

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Transcription of the Human Genes for Cytochrome P450scc and P450c17 Is Regulated Differently in Human Adrenal NCI-H295 Cells Than in Mouse Adrenal Y1 Cells

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Contribution of Ad4BP, a steroidogenic cell-specific transcription factor, to regulation of the human CYP11A and bovine CYP11B genes through their distal promoters

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The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis

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Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade

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A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.

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Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids

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The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus

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Phosphorylated CREB binds specifically to the nuclear protein CBP

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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

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Nuclear protein CBP is a coactivator for the transcription factor CREB

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Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator

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A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

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The CBP co-activator is a histone acetyltransferase

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Identifiers

DOI

10.1074/JBC.273.8.4585

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9468515%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference