Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase (Q40934280)

25 September 2017

title

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase (English)

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25 September 2017

L A Parrott

1

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25 September 2017

D J Templeton

series ordinal

2

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25 September 2017

language of work or name

English

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publication date

1 August 1999

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Journal of Biological Chemistry

25 September 2017

published in

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25 September 2017

volume

274

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25 September 2017

issue

35

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25 September 2017

page(s)

24731-24736

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The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation

25 September 2017

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The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

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Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

21 January 2018

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Cdc2-cyclin B phosphorylates p70 S6 kinase on Ser411 at mitosis

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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Intracellular signalling: PDK1--a kinase at the hub of things

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Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

21 January 2018

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Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains

21 January 2018

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Identification and characterization of a mitogen-activated S6 kinase

21 January 2018

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

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Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

21 January 2018

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21 January 2018

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

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Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun

21 January 2018

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Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

21 January 2018

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Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

21 January 2018

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21 January 2018

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21 January 2018

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Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

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Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

21 January 2018

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21 January 2018

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

21 January 2018

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Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

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Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

21 January 2018

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

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Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

21 January 2018

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The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

21 January 2018

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Requirement of the serine-threonine kinase Akt for heat treatment-induced activation of p70 S6 kinase

21 January 2018

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Selective and reversible inhibition of initiation of protein synthesis in mammalian cells.

21 January 2018

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Lipid-Regulated Kinases: Some Common Themes at Last

21 January 2018

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p70s6k function is essential for G1 progression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.35.24731

1 reference

25 September 2017

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