Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent (Q40848107)

24 September 2017

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title

Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent (English)

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24 September 2017

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L H Patterson

1

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24 September 2017

publication date

1 June 1993

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Cancer and Metastasis Reviews

24 September 2017

published in

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24 September 2017

volume

12

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24 September 2017

issue

2

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24 September 2017

page(s)

119-134

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DNA strand breakage by peroxidase-activated mitoxantrone

24 September 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FBF00689805

Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450

21 January 2018

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12 December 2020

Catalytic function of DNA topoisomerase II.

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12 December 2020

Lack of involvement of reactive oxygen in the cytotoxicity of mitoxantrone, CI941 and ametantrone in MCF-7 cells: comparison with doxorubicin

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12 December 2020

Comparison of Antineoplastic Activity of Aminoethylaminoanthraquinones and Anthracycline Antibiotics

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12 December 2020

Conformational flexibility of dinucleoside dimers during unwinding from the B-form to an intercalation structure

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12 December 2020

Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone

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12 December 2020

Iron-EDTA stimulated reduction of indicine N-oxide by the hepatic microsomal fraction, isolated hepatocytes, and the intact rat

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12 December 2020

Differential oxygen radical susceptibility of adriamycin-sensitive and -resistant MCF-7 human breast tumor cells

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12 December 2020

Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopy

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12 December 2020

Mitoxantrone affects topoisomerase activities in human breast cancer cells

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12 December 2020

Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells

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12 December 2020

DNA topoisomerase poisons as antitumor drugs

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12 December 2020

Reductive drug metabolism.

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12 December 2020

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

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12 December 2020

Tumor hypoxia, reoxygenation and oxygenation strategies: possible role in photodynamic therapy

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12 December 2020

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

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12 December 2020

N-Oxide reduction by hemoglobin, cytochrome C and ferrous ions

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12 December 2020

Persistent intracellular binding of mitoxantrone in a human colon carcinoma cell line

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12 December 2020

Analogues of tamoxifen: the role of the basic side-chain. Applications of a whole-cell oestrogen-receptor binding assay to N-oxides and quaternary salts

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12 December 2020

Non-invasive assessment of human tumour hypoxia with 123I-iodoazomycin arabinoside: preliminary report of a clinical study

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12 December 2020

Toxicity of nitro compounds toward hypoxic mammalian cells in vitro: dependence on reduction potential

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12 December 2020

Regional blood flow in human tumors

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12 December 2020

Bioreductive mechanisms

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12 December 2020

Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data

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12 December 2020

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

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12 December 2020

DT-diaphorase and cancer chemotherapy

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12 December 2020

Hypoxic fractions of human tumors xenografted into mice: a review

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12 December 2020

Synthesis and anticancer activity of cytosine arabinoside 3-N-oxide (ara-C 3-N-oxide)

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12 December 2020

Experimental antitumor activity of aminoanthraquinones

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12 December 2020

Synthesis and antineoplastic evaluation of 1,4-bis(aminoalkanamido)-9,10-anthracenediones

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12 December 2020

Horseradish peroxidase-catalyzed oxidation of mitoxantrone: spectrophotometric and electron paramagnetic resonance studies

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12 December 2020

Dissociation kinetics of DNA-anthracycline and DNA-anthraquinone complexes determined by stopped-flow spectrophotometry

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12 December 2020

DNA-binding specificity and RNA polymerase inhibitory activity of bis(aminoalkyl)anthraquinones and bis(methylthio)vinylquinolinium iodides

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12 December 2020

Synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogues and their N-oxides. Potential antitumor agents

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12 December 2020

DNA sequence preferences for the anti-cancer drug mitoxanthrone and related anthraquinones revealed by DNase I footprinting

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12 December 2020

Semisynthetic pyrrolizidine alkaloid N-oxide antitumor agents. Esters of heliotridine

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12 December 2020

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

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12 December 2020

Reduction of tertiary amine N-oxides by cytochrome P-450. Mechanism of the stimulatory effect of flavins and methyl viologen

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12 December 2020

Reduction in vivo of (−)-nicotine-1′-N-oxide by germ-free and conventional rats

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12 December 2020

Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone

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12 December 2020

The enzymatic reduction of nicotinamide N-oxide

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12 December 2020

Pyridine nucleotide cofactor requirements of indicine N-oxide reduction by hepatic microsomal cytochrome P-450

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12 December 2020

Kinetics of the binding of mitoxantrone, ametantrone and analogues to DNA: relationship with binding mode and anti-tumour activity

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12 December 2020

Interactions of a new antitumor agent, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]-ethyl]amino]-9,10-anthracenedione, with nucleic acids

1 reference

12 December 2020

A theoretical investigation on the sequence selective binding of mitoxantrone to double-stranded tetranucleotides

1 reference

12 December 2020

Reduced nicotinamide adenine dinucleotide-dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450

1 reference

12 December 2020

High field 1H-NMR analysis of the 1:1 intercalation complex of the antitumor agent mitoxantrone and the DNA duplex [d(CpGpCpG)]

1 reference

12 December 2020

Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids

1 reference

12 December 2020

Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analyzed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage

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12 December 2020

The metabolism of chlorpromazine by liver microsomal enzyme systems

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12 December 2020

Action of dihydroxyanthraquinone on cell cycle progression and survival of a variety of cultured mammalian cells

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12 December 2020

The design, synthesis and development of a new class of potent antineoplastic anthraquinones

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12 December 2020

Toxicity and metabolism of 3'-deoxyadenosine N1-oxide in mice and Ehrlich ascites tumor cells

1 reference

12 December 2020

Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone

1 reference

12 December 2020

Indicine N-oxide: clinical use of a pyrrolizidine alkaloid

1 reference

12 December 2020

Interaction of the peroxidase-derived metabolite of mitoxantrone with nucleic acids. Evidence for covalent binding of 14C-labeled drug

1 reference

12 December 2020

Catalysis of the direct transfer of oxygen from nicotinamide N-oxide to xanthine by xanthine oxidase

1 reference

12 December 2020

NAD (P) H-dependent reduction of nicotinamide N-oxide by an unique enzyme system consisting of liver microsomal NADPH-cytochrome c reductase and cytosolic aldehyde oxidase

1 reference

12 December 2020

NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals

1 reference

12 December 2020

Bis-bioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide

1 reference

12 December 2020

Structure-activity relationship study of anthraquinones: 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9,10-anthracenedione, an analog of an established antineoplastic agent

1 reference

12 December 2020

Properties of an N,N-dimethyl-p-aminoazobenzene oxide reductase purified from rat liver cytosol

1 reference

12 December 2020

Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].poly[d(G-C)], and poly[d(A-T)].poly[d(A-T)]

1 reference

12 December 2020

The interaction of aminoalkylaminoanthraquinones with deoxyribonucleic acid

1 reference

12 December 2020

The reduction of nicotinamide N-oxide by xanthine oxidase

1 reference

12 December 2020

Localization of tumors and evaluation of their state of oxygenation by phosphorescence imaging

1 reference

12 December 2020

Evaluation of the binding of some substituted anthraquinones and naphthacenequinones to DNA

1 reference

12 December 2020

Bis(alkylamino)anthracenedione antineoplastic agent metabolic activation by NADPH-cytochrome P-450 reductase and NADH dehydrogenase: diminished activity relative to anthracyclines.

1 reference

12 December 2020

Sensitization of hypoxic tumour cells--clinical experience

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12 December 2020

Involvement of hydroxyl radical formation and DNA strand breakage in the cytotoxicity of anthraquinone antitumour agents

1 reference

12 December 2020

DNA topoisomerase dysfunction: a new goal for antitumor chemotherapy

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12 December 2020

Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity

1 reference

12 December 2020

Reductive activation of N-oxides to cause DNA strand breakage in cell lines in vitro

1 reference

12 December 2020

Comparative molecular pharmacology in leukemic L1210 cells of the anthracene anticancer drugs mitoxantrone and bisantrene

1 reference

12 December 2020

Involvement of liver aldehyde oxidase in the reduction of nicotinamide N-oxide

1 reference

12 December 2020

Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones

1 reference

12 December 2020

The pharmacology and biochemistry of N-oxides

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12 December 2020

Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical

1 reference

12 December 2020

Evidence for impaired mitoxantrone and vinblastine binding in P388 murine leukemia cells with multidrug resistance

1 reference

12 December 2020

Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. I. Tricyclic tertiary amine drugs

1 reference

12 December 2020

Relationship between the pharmacological activity of antitumor drugs Ametantrone and mitoxantrone (Novatrone) and their ability to condense nucleic acids

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00689805

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Dimensions Publication ID

24 September 2017

1027992179

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