The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. (Q40789796)

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19 October 2019

title

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain (English)

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19 October 2019

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1 reference

Nicholas A. Williamson

4

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19 October 2019

Rick Pearson

1

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19 October 2019

author name string

Dennis PB

2

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19 October 2019

Han JW

3

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19 October 2019

Kozma SC

5

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19 October 2019

Wettenhall RE

6

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19 October 2019

Thomas G

7

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19 October 2019

language of work or name

English

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publication date

1 November 1995

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19 October 2019

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19 October 2019

volume

14

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19 October 2019

issue

21

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19 October 2019

page(s)

5279-5287

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

19 October 2019

cites work

1 reference

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PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

24 September 2017

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

24 September 2017

1 reference

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Nuclear localization of p85s6k: functional requirement for entry into S phase.

24 September 2017

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

24 September 2017

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

24 September 2017

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p70s6k/p85s6k: mechanism of activation and role in mitogenesis.

24 September 2017

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Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

24 September 2017

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Multiple independent inputs are required for activation of the p70 S6 kinase

24 September 2017

1 reference

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Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

24 September 2017

1 reference

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

24 September 2017

1 reference

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Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

24 September 2017

1 reference

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A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases

24 September 2017

1 reference

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SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits

24 September 2017

1 reference

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S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment

24 September 2017

1 reference

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Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase

24 September 2017

1 reference

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Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

24 September 2017

1 reference

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Identification of a protein kinase multigene family of Dictyostelium discoideum: molecular cloning and expression of a cDNA encoding a developmentally regulated protein kinase

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Molecular cloning of a second form of rac protein kinase

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Epitope tagging and protein surveillance

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

24 September 2017

1 reference

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Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

24 September 2017

1 reference

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A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

24 September 2017

1 reference

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Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

24 September 2017

1 reference

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

24 September 2017

1 reference

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Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation

24 September 2017

1 reference

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Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

24 September 2017

1 reference

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Activation of p70/p85 S6 kinase by a pathway independent of p21ras

24 September 2017

1 reference

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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

25 September 2017

1 reference

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Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Structure and expression of a novel, neuronal protein kinase C (PKC1B) from Caenorhabditis elegans. PKC1B is expressed selectively in neurons that receive, transmit, and process environmental signals

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Isolation of a yeast protein kinase gene by screening with a mammalian protein kinase cDNA.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

A fourth type of rabbit protein kinase C.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

The structure, expression, and properties of additional members of the protein kinase C family

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Purification and properties of mitogen-activated S6 kinase from rat liver and 3T3 cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Solid-phase sequencing of 32P-labeled phosphopeptides at picomole and subpicomole levels

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expression.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=394637

Hot lips and phosphorylation of protein kinases

2 December 2018

1 reference

12 December 2020

p70s6k function is essential for G1 progression

1 reference

12 December 2020

The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites

1 reference

12 December 2020

Functional carboxyl terminal deletion map of protein kinase C alpha

1 reference

12 December 2020

10.1002/J.1460-2075.1995.TB00212.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7489717%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7489717%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

PubMed publication ID

7489717

1 reference