The SCID mouse: relevance as an animal model system for studying human disease. (Q40788237)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8256843%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

review article

1 reference

title

The SCID mouse: relevance as an animal model system for studying human disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8256843%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

author name string

Hendrickson EA

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8256843%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

language of work or name

English

0 references

publication date

1 December 1993

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8256843%20AND%20SRC:MED&resulttype=core&format=json

The American Journal of Pathology

28 October 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8256843%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

volume

143

1 reference

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28 October 2019

issue

6

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28 October 2019

page(s)

1511-1522

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8256843%20AND%20SRC:MED&resulttype=core&format=json

Hemopoietic stem-cell compartment of the SCID mouse: double-exponential survival curve after gamma irradiation

28 October 2019

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Recombinase activating gene expression in thymic subpopulations. A transitional cell type has lost RAG-2 but not RAG-1.

24 September 2017

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24 September 2017

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24 September 2017

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24 September 2017

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X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

24 September 2017

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Evidence of functional lymphocytes in some (leaky) scid mice

24 September 2017

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Identification of a DNA binding protein that recognizes the nonamer recombinational signal sequence of immunoglobulin genes.

24 September 2017

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Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction

24 September 2017

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Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints

24 September 2017

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The V(D)J recombination activating gene, RAG-1.

24 September 2017

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A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

24 September 2017

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

24 September 2017

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T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors

24 September 2017

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Wild-type V(D)J recombination in scid pre-B cells

24 September 2017

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Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice

24 September 2017

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Strand breaks without DNA rearrangement in V (D)J recombination

24 September 2017

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scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

24 September 2017

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Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiency

24 September 2017

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The SCID-hu mouse: a small animal model for HIV infection and pathogenesis

24 September 2017

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The SCID mouse mutant: definition, characterization, and potential uses

24 September 2017

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Preclinical Evaluation of Human Hematolymphoid Function in the SCID-hu Mouse

24 September 2017

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A link between double-strand break-related repair and V(D)J recombination: the scid mutation

24 September 2017

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hu-PBL-SCID Mice: A Model for Human Immune Function, AIDS, and Lymphomagenesis

24 September 2017

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24 September 2017

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RAG-1-deficient mice have no mature B and T lymphocytes

24 September 2017

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

24 September 2017

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The mechanism of V(D)J recombination: a balance of diversity, specificity, and stability

24 September 2017

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24 September 2017

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Activation of V(D)J recombination by RAG1 and RAG2

24 September 2017

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V(D)J recombination gets a break

24 September 2017

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24 September 2017

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Molecular analysis of V(D)J recombination

24 September 2017

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The beige mutation in the mouse selectively impairs natural killer cell function

24 September 2017

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Detection and characterization of functional T cells in mice with severe combined immune deficiency

24 September 2017

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V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

25 September 2017

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Establishment of a karyotypically normal cytotoxic leukemic T-cell line from a T-ALL sample engrafted in SCID mice.

15 June 2018

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Impairment of V(D)J recombination in double-strand break repair mutants

15 June 2018

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15 June 2018

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RAG-1 and RAG-2 are not sufficient to direct all phases of immunoglobulin gene rearrangement in pre-B-cell lines

15 June 2018

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Human chromosome 8 (p12-->q22) complements radiosensitivity in the severe combined immune deficiency (SCID) mouse.

15 June 2018

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15 June 2018

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Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

15 June 2018

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15 June 2018

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The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

15 June 2018

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Unusual immunoglobulin gene rearrangement leads to replacement of recombinational signal sequences

15 June 2018

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The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

15 June 2018

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Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice

15 June 2018

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Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.

15 June 2018

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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

15 June 2018

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A model of human acute lymphoblastic leukemia in immune-deficient SCID mice

15 June 2018

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Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

15 June 2018

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Cell cycle responses of two X-ray sensitive mutants defective in DNA repair

15 June 2018

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Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments

15 June 2018

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The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?

15 June 2018

1 reference

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Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion

15 June 2018

1 reference

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The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

15 June 2018

1 reference

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Defective repair of radiation-induced chromosomal damage in scid/scid mice

15 June 2018

1 reference

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Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture

15 June 2018

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Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice

15 June 2018

1 reference

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A fourth complementation group among ionizing radiation-sensitive Chinese hamster cell mutants defective in DNA double-strand break repair

15 June 2018

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Analysis of the defect in DNA end joining in the murine scid mutation

15 June 2018

1 reference

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Heterogeneity among Epstein-Barr virus-seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts

15 June 2018

1 reference

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Scid mouse Pre-B cells with intracellular mu chains: analysis of recombinase activity and IgH gene rearrangements

15 June 2018

1 reference

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The fate of human peripheral blood lymphocytes after transplantation into SCID mice

19 August 2018

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Characterization of the DNA double strand break repair defect in scid mice

19 August 2018

1 reference

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The mouse severe combined immune deficiency (scid) mutation is closely linked to the B-cell-specific developmental genes VpreB and lambda 5.

19 August 2018

1 reference

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EBV human B-cell lymphomas in Scid mice: description of the model and study of the role of anti-CD40 and anti-CD23 monoclonal antibodies in their development

19 August 2018

1 reference

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Comparative studies between nude and scid mice on the growth and metastatic behavior of xenografted human tumors

19 August 2018

1 reference

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Implantation and maintenance of functional human bone marrow in SCID-hu mice

19 August 2018

1 reference

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The scid mutation in mice causes a general defect in DNA repair

19 August 2018

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12 December 2020

Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints

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12 December 2020

Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation

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12 December 2020

CD4+CD8- thymocytes from neonatal mice induce IgM production in SCID mice

1 reference

12 December 2020

Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice

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12 December 2020

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

1 reference

12 December 2020

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease

1 reference

12 December 2020

Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells

1 reference

12 December 2020

Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients

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12 December 2020

Transfer of a functional human immune system to mice with severe combined immunodeficiency

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12 December 2020

Engraftment of immune-deficient mice with human hematopoietic stem cells

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12 December 2020

Novel strand exchanges in V(D)J recombination

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12 December 2020

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement

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12 December 2020

Occurrence of mature B (IgM+, B220+) and T (CD3+) lymphocytes in scid mice

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12 December 2020

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

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12 December 2020

Tumors arising in SCID mice share enhanced radiation sensitivity of SCID normal tissues

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12 December 2020

hu-PBL-SCID mice can be protected from HIV-1 infection by passive transfer of monoclonal antibody to the principal neutralizing determinant of envelope gp120

1 reference

12 December 2020

Anti-B4-blocked ricin immunotoxin shows therapeutic efficacy in four different SCID mouse tumor models

1 reference

12 December 2020

Comparative abilities of athymic nude mice and severe combined immune deficient (SCID) mice to accept transplants of induced rat mammary carcinomas: enhanced transplantation efficiency of those rat mammary carcinomas that have elevated expression of

1 reference

12 December 2020

Strain-dependent leakiness of mice with severe combined immune deficiency

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12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8256843%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

PubMed publication ID

8256843

1 reference