S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function (Q40769630)

23 September 2017

title

S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function (English)

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23 September 2017

4

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23 September 2017

William A Cliby

1

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23 September 2017

Kriste A Lewis

series ordinal

2

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23 September 2017

Kia K Lilly

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

7 November 2001

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

issue

2

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23 September 2017

page(s)

1599-1606

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

23 September 2017

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells

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Regulation of chromosome replication

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Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks

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Exposure to camptothecin breaks leading and lagging strand simian virus 40 DNA replication forks

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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Targeting double-strand breaks to replicating DNA identifies a subpathway of DSB repair that is defective in ataxia-telangiectasia cells.

21 January 2018

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Roadblocks and detours during DNA replication: mechanisms of mutagenesis in mammalian cells

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A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

21 January 2018

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

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Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M106287200

1 reference

release_mu3gzxsr55d27lp2zkv5yzkxsq

23 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mu3gzxsr55d27lp2zkv5yzkxsq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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