Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice (Q40762438)

23 September 2017

title

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice (English)

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23 September 2017

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Brodie SG

1

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23 September 2017

Xu X

2

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23 September 2017

Qiao W

3

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23 September 2017

Li WM

4

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23 September 2017

Cao L

5

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23 September 2017

Deng CX

6

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23 September 2017

language of work or name

English

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publication date

1 November 2001

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23 September 2017

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23 September 2017

volume

20

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23 September 2017

issue

51

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23 September 2017

page(s)

7514-7523

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BRCA1-associated growth arrest is RB-dependent

23 September 2017

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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Apoptosis in anititumor strategies: Modulation of cell cycle or differentiation

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Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Apoptosis in cancer therapy: crossing the threshold

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BRCA1 mutations in primary breast and ovarian carcinomas

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

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BRCA1 required for transcription-coupled repair of oxidative DNA damage

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

21 January 2018

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

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Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53

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Transgenic mouse models of human breast cancer

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BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

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Cancer-susceptibility genes. Gatekeepers and caretakers

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Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development

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Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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Role of HER2 gene overexpression in breast carcinoma

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Brca1 controls homology-directed DNA repair

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Casein kinase 2 binds to and phosphorylates BRCA1.

21 January 2018

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17q21-q25 aberrations in breast cancer: combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification

21 January 2018

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BRCA1: a review of structure and putative functions

21 January 2018

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BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

21 January 2018

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

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Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases

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BRCA1 and cell signaling

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BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

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Identification of a RING protein that can interact in vivo with the BRCA1 gene product

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Mutations of the BRCA1 gene in human cancer

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

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The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

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7 January 2021

p27kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up

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7 January 2021

Deletion mapping of chromosomal region 1p32-pter in primary breast cancer

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7 January 2021

Gene amplification and tumor progression

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7 January 2021

Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis

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7 January 2021

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7 January 2021

Genetic background alters the spectrum of tumors that develop in p53-deficient mice

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7 January 2021

Tumour biological features of BRCA1-induced breast and ovarian cancer

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7 January 2021

Expression of cell cycle-regulatory proteins rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: correlations with expression of activating protein-1 family members

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7 January 2021

At least five regions of imbalance on 6q in breast tumors, combining losses and gains

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7 January 2021

Multiple copies of mutantBRCA1 andBRCA2 alleles in breast tumors from germ-line mutation carriers

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7 January 2021

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

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7 January 2021

Oestrogen receptor and its potential role in breast cancer development

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204929

1 reference

Dimensions Publication ID

23 September 2017

1023709287

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1 reference