Identification and characterization of presenilin-independent Notch signaling (Q40760805)

23 September 2017

title

Identification and characterization of presenilin-independent Notch signaling (English)

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23 September 2017

Bridget E Berechid

1

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23 September 2017

Magali Kitzmann

2

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23 September 2017

Daniel R Foltz

3

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23 September 2017

Arthur H Roach

4

1 reference

23 September 2017

Dietmar Seiffert

5

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23 September 2017

Lorin A Thompson

6

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23 September 2017

Richard E Olson

7

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23 September 2017

Alan Bernstein

8

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23 September 2017

Dorit B Donoviel

9

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23 September 2017

Jeffrey S Nye

10

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23 September 2017

language of work or name

English

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publication date

26 December 2001

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

issue

10

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23 September 2017

page(s)

8154-8165

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https://api.crossref.org/works/10.1074%2FJBC.M108238200

23 September 2017

1 reference

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Notch1 is essential for postimplantation development in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Maintenance of somite borders in mice requires the Delta homologue DII1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Evidence for a physical interaction between presenilin and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Lack of requirement for presenilin1 in Notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

The Ins and Outs of Notch Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

The Notch pathway: democracy and aristocracy in the selection of cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Nuclear access and action of notch in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Signalling downstream of activated mammalian Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Numb antagonizes Notch signaling to specify sibling neuron cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

The presenilins in Alzheimer's disease--proteolysis holds the key.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Delta-mediated specification of midline cell fates in zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Nuclear Notch1 signaling and the regulation of dendritic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

Requirement of Notch in adulthood for neurological function and longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108238200

21 January 2018

Identifiers

DOI

10.1074/JBC.M108238200

1 reference

23 September 2017

1 reference