Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. (Q40690737)

PubMed publication ID

12427828

22 September 2017

title

Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757822&resulttype=core&format=json

12 May 2020

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Thomas Fath

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757822&resulttype=core&format=json

12 May 2020

Jochen Eidenmüller

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757822&resulttype=core&format=json

12 May 2020

Roland Brandt

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757822&resulttype=core&format=json

12 May 2020

language of work or name

English

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publication date

1 November 2002

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PubMed publication ID

12427828

22 September 2017

published in

Journal of Neuroscience

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12 May 2020

volume

22

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12 May 2020

issue

22

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757822&resulttype=core&format=json

12 May 2020

page(s)

9733-9741

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Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins

12 May 2020

cites work

1 reference

12 December 2020

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

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12 December 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

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12 December 2020

Neurotrophins differentially regulate the survival and morphological complexity of human CNS model neurons.

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12 December 2020

cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons

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12 December 2020

Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells).

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12 December 2020

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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12 December 2020

Caspase-2 mediates neuronal cell death induced by beta-amyloid

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12 December 2020

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

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12 December 2020

Apoptosis in neural development and disease

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12 December 2020

Apoptosis in the nervous system

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12 December 2020

Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins.

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12 December 2020

Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells

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12 December 2020

The world according to PARP.

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12 December 2020

Apoptosis in neurodegenerative disorders

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12 December 2020

Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology

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12 December 2020

Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein

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12 December 2020

Neurodegenerative tauopathies

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12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Tau phosphorylation during apoptosis of human SH-SY5Y neuroblastoma cells

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12 December 2020

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

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12 December 2020

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

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12 December 2020

Tau is essential to beta -amyloid-induced neurotoxicity

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12 December 2020

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

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12 December 2020

Molecular characterization of microtubule-associated proteins tau and MAP2.

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12 December 2020

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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12 December 2020

Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line

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12 December 2020

Tau isoform expression and phosphorylation state during differentiation of cultured neuronal cells

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12 December 2020

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

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12 December 2020

Evidence for apoptotic cell death in Alzheimer's disease.

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12 December 2020

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

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12 December 2020

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

1 reference

12 December 2020

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

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12 December 2020

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

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12 December 2020

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

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12 December 2020

Inhibition of drug-induced apoptosis by survival factors in PC12 cells

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12 December 2020

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

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12 December 2020

Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation.

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12 December 2020

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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12 December 2020

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

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12 December 2020

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

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12 December 2020

Functional studies of Alzheimer's disease tau protein

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12 December 2020

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

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12 December 2020

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

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12 December 2020

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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12 December 2020

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

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12 December 2020

Caspases: enemies within

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12 December 2020

Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid

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12 December 2020

10.1523/JNEUROSCI.22-22-09733.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757822&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757822&resulttype=core&format=json

12 May 2020

PubMed publication ID

12427828

1 reference