Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. (Q40340003)

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scientific article published on December 2005

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English	Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.	scientific article published on December 2005

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 September 2017

Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation (English)

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12 May 2020

phosphorylation

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Ping Han

1

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12 May 2020

Fei Dou

2

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12 May 2020

Feng Li

3

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12 May 2020

Xue Zhang

4

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12 May 2020

Yun-Wu Zhang

5

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12 May 2020

Hui Zheng

6

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12 May 2020

Stuart A Lipton

7

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12 May 2020

Huaxi Xu

8

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12 May 2020

Francesca-Fang Liao

9

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12 May 2020

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publication date

1 December 2005

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19 September 2017

Journal of Neuroscience

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12 May 2020

25

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12 May 2020

50

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12 May 2020

11542-11552

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12 May 2020

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and molecular basis of beta-amyloid precursor protein metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium regulates the association between mitochondria and a smooth subdomain of the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The receptor-bound N-terminal ectodomain of the amyloid precursor protein is associated with membrane rafts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5: One of the links between senile plaques and neurofibrillary tangles?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity in the mechanisms of neuronal cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5--a neuronal killer?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable-tau overexpression in human neuroblastoma cells: an open door for explaining neuronal death in tauopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5: mediator of neuronal death and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathways to neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balancing neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau pathology in Alzheimer disease and other tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate increases tau phosphorylation in primary neuronal cultures from fetal rat cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic and neuroprotective effects of hAPP in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16354912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3831-05.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6726015&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6726015&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6726015&resulttype=core&format=json

12 May 2020

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