Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations (Q40318729)

19 September 2017

title

Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations (English)

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19 September 2017

main subject

myelodysplastic syndrome

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Niimi H

1

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19 September 2017

Harada H

2

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19 September 2017

Harada Y

3

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19 September 2017

Ding Y

4

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19 September 2017

Imagawa J

5

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19 September 2017

Inaba T

6

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19 September 2017

Kyo T

7

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19 September 2017

Kimura A

8

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19 September 2017

publication date

1 April 2006

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19 September 2017

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19 September 2017

volume

20

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19 September 2017

issue

4

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19 September 2017

page(s)

635-644

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Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation

19 September 2017

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

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Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

21 January 2018

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High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia

21 January 2018

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 January 2018

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

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Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype

21 January 2018

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Chromosome and molecular abnormalities in myelodysplastic syndromes

21 January 2018

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Molecular mechanisms of myelodysplastic syndrome

21 January 2018

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A hypothesis for the pathogenesis of myelodysplastic syndromes: implications for new therapies.

21 January 2018

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CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication.

21 January 2018

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Systemic mastocytosis with associated clonal hematological non‐mast‐cell lineage disease: Analysis of clinicopathologic features and activating c‐kit mutations

21 January 2018

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PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

21 January 2018

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

21 January 2018

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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

21 January 2018

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

21 January 2018

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Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

21 January 2018

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Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities

21 January 2018

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Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.

21 January 2018

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Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia.

21 January 2018

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A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

21 January 2018

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Mutations in PTPN11 are uncommon in adult myelodysplastic syndromes and acute myeloid leukaemia

21 January 2018

1 reference

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Mutations in PTPN11 are rare in adult myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

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Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia

21 January 2018

1 reference

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Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

21 January 2018

1 reference

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Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

21 January 2018

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Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

21 January 2018

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Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

21 January 2018

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

21 January 2018

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

21 January 2018

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Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells

21 January 2018

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Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.

21 January 2018

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Role of nucleophosmin in embryonic development and tumorigenesis

21 January 2018

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Identification of RUNX1/AML1 as a classical tumor suppressor gene

21 January 2018

1 reference

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7 January 2021

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

NF1 gene analysis based on DHPLC

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor progno

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Possible co-existence of RAS activation and monosomy 7 in the leukaemic transformation of myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to replication error phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Neurofibromatosis 1 gene (NF1) mutation is a rare genetic event in myelodysplastic syndrome regardless of the disease progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404136

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2404136

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Dimensions Publication ID

19 September 2017

1035975191

0 references

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