Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology (Q40227379)

18 September 2017

title

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology (English)

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18 September 2017

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Stéphane Duvezin-Caubet

object named as

Stéphane Duvezin-Caubet

1

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Johannes Wagener

object named as

Johannes Wagener

3

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Nils-Göran Larsson

10

object named as

Nils-Göran Larsson

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18 September 2017

Ravi Jagasia

2

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18 September 2017

Sabine Hofmann

4

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18 September 2017

Aleksandra Trifunovic

5

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18 September 2017

Anna Hansson

6

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18 September 2017

Anne Chomyn

7

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18 September 2017

Matthias F Bauer

8

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18 September 2017

Giuseppe Attardi

9

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18 September 2017

Walter Neupert

11

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18 September 2017

Andreas S Reichert

12

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18 September 2017

language of work or name

English

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publication date

26 September 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

281

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18 September 2017

issue

49

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18 September 2017

page(s)

37972-37979

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

18 September 2017

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OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

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Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

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Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

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Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation

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Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

21 January 2018

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OPA1 requires mitofusin 1 to promote mitochondrial fusion

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Disruption of fusion results in mitochondrial heterogeneity and dysfunction

21 January 2018

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Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria

21 January 2018

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21 January 2018

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Identifiers

DOI

10.1074/JBC.M606059200

1 reference

18 September 2017

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