Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. (Q40139351)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

title

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Cláudia Guimas Almeida

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

author name string

Davide Tampellini

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Jordi Magrané

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Reisuke H Takahashi

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Feng Li

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Michael T Lin

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

language of work or name

English

0 references

publication date

27 April 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

30 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

volume

282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

issue

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

page(s)

18895-18906

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

30 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Alzheimer's disease and immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Immunology and immunotherapy of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Intraneuronal Abeta42 accumulation in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Gleevec inhibits β-amyloid production but not Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

A dynamic relationship between intracellular and extracellular pools of Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700373200

21 January 2018

Identifiers

DOI

10.1074/JBC.M700373200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17468102%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference