The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells (Q39954622)

15 September 2017

The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells (English)

1 reference

15 September 2017

Wei Huang

1

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15 September 2017

Emily E Martin

2

1 reference

15 September 2017

Boris Burman

3

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15 September 2017

Maria E Gonzalez

4

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15 September 2017

Celina G Kleer

5

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15 September 2017

language of work or name

English

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publication date

25 February 2016

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15 September 2017

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15 September 2017

7

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15 September 2017

18

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15 September 2017

25180-25193

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describes a project that uses

15 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5041896/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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CCN6 knockdown disrupts acinar organization of breast cells in three-dimensional cultures through up-regulation of type III TGF-β receptor

22 September 2017

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CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer

22 September 2017

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Slug and Sox9 cooperatively determine the mammary stem cell state

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CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer

22 September 2017

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Histone Methyltransferase EZH2 Induces Akt-Dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer

22 September 2017

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CCN6 enhances ICAM‐1 expression and cell motility in human chondrosarcoma cells

22 September 2017

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Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate

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Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells

22 September 2017

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22 September 2017

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Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis

22 September 2017

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

22 September 2017

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22 September 2017

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22 September 2017

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Slug is a direct Notch target required for initiation of cardiac cushion cellularization

22 September 2017

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Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast

22 September 2017

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The epithelial-mesenchymal transition generates cells with properties of stem cells

22 September 2017

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Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion

22 September 2017

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

22 September 2017

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Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.

22 September 2017

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Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

22 September 2017

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The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling

22 September 2017

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22 September 2017

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Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer

22 September 2017

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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

22 September 2017

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The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

22 September 2017

1 reference

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CCN family proteins and angiogenesis: from embryo to adulthood

22 September 2017

1 reference

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All in the CCN family: essential matricellular signaling modulators emerge from the bunker

22 September 2017

1 reference

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Generation of a functional mammary gland from a single stem cell

22 September 2017

1 reference

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CCN proteins and cancer: two to tango

22 September 2017

1 reference

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Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61)

22 September 2017

1 reference

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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

22 September 2017

1 reference

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Proposal for a unified CCN nomenclature

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.

22 September 2017

1 reference

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Matricellular proteins: extracellular modulators of cell function

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Epithelial-mesenchymal transitions in tumour progression

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Stromal effects on mammary gland development and breast cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

The SLUG zinc-finger protein represses E-cadherin in breast cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Putting tumours in context

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

22 September 2017

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

WISP3 is a novel tumor suppressor gene of inflammatory breast cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Dysregulated expression of Slug, vimentin, and E-cadherin correlates with poor clinical outcome in patients with basal-like breast cancer

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Report on the fourth international workshop on the CCN family of genes

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

Notch1 expression in early lymphopoiesis influences B versus T lineage determination

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5041896

20 August 2018

Identifiers

DOI

10.18632/ONCOTARGET.7734

1 reference

15 September 2017

1 reference

15 September 2017

PubMed publication ID

26933820

1 reference