Isolation of hyperactive mutants of mammalian target of rapamycin (Q39936654)

15 September 2017

title

Isolation of hyperactive mutants of mammalian target of rapamycin (English)

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15 September 2017

6

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15 September 2017

Yoichiro Ohne

1

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15 September 2017

Terunao Takahara

2

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15 September 2017

Riko Hatakeyama

3

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15 September 2017

Tomoko Matsuzaki

4

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15 September 2017

Makoto Noda

5

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15 September 2017

Tatsuya Maeda

7

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15 September 2017

language of work or name

English

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publication date

23 September 2008

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Journal of Biological Chemistry

15 September 2017

published in

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15 September 2017

volume

283

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15 September 2017

issue

46

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15 September 2017

page(s)

31861-31870

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Signaling by target of rapamycin proteins in cell growth control

15 September 2017

cites work

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TOR signaling in growth and metabolism

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region

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Molecular organization of target of rapamycin complex 2.

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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

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Drosophila target of rapamycin kinase functions as a multimer.

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Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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Tor-mediated induction of autophagy via an Apg1 protein kinase complex

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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TOR2 is required for organization of the actin cytoskeleton in yeast

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An expanding role for mTOR in cancer

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

21 January 2018

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Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p.

21 January 2018

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Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells

21 January 2018

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Regulation and role of autophagy in mammalian cells

21 January 2018

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Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway

21 January 2018

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Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes

21 January 2018

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How to interpret LC3 immunoblotting

21 January 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

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The conformational plasticity of protein kinases

21 January 2018

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A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases

21 January 2018

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

21 January 2018

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

21 January 2018

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

21 January 2018

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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

21 January 2018

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Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M801546200

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15 September 2017

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