APC and the three-hit hypothesis (Q39932292)

15 September 2017

title

APC and the three-hit hypothesis (English)

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15 September 2017

12

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11

E J Sawyer

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13

I P M Tomlinson

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15 September 2017

S Segditsas

1

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A J Rowan

2

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K Howarth

3

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A Jones

4

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S Leedham

5

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N A Wright

6

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P Gorman

7

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W Chambers

8

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E Domingo

9

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R R Roylance

10

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15 September 2017

language of work or name

English

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publication date

6 October 2008

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15 September 2017

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15 September 2017

volume

28

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15 September 2017

issue

1

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15 September 2017

page(s)

146-155

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The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

15 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FONC.2008.361

DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.361

Disease model: familial adenomatous polyposis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.361

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.361

Two genetic hits (more or less) to cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.361

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Can chromosomal instability initiate tumorigenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.361

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Tissue, cell and stage specificity of (epi)mutations in cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.361

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.361

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Dimensions Publication ID

15 September 2017

1032035894

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