The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels. (Q39876267)

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English	The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels.	scientific article

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22 January 2020

The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels (English)

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22 January 2020

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22 January 2020

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22 January 2020

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22 January 2020

Chia-Hsiang Hsueh

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Chia-Hsiang Hsueh

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22 January 2020

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Chun-Wu Chen

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22 January 2020

Yi-Ning Su

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22 January 2020

Mark J Shen

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22 January 2020

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6 March 2009

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22 January 2020

Journal of Human Genetics

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22 January 2020

54

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22 January 2020

4

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22 January 2020

242-247

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22 January 2020

Atherosclerosis — An Inflammatory Disease

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The sterol-sensing domain: multiple families, a unique role?

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21 January 2018

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

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Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

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21 January 2018

NPC1L1: evolution from pharmacological target to physiological sterol transporter

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Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells.

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21 January 2018

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake

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21 January 2018

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

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21 January 2018

Regulation of intestinal cholesterol absorption

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21 January 2018

Molecular mechanisms of cholesterol absorption and transport in the intestine

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ATP-Binding cassette cholesterol transporters and cardiovascular disease

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Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

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Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity

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21 January 2018

LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2.

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21 January 2018

Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2.

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NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe

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21 January 2018

Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment

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Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

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Sterol mediated regulation of SREBP-1a,1b,1c and SREBP-2 in cultured human cells

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SREBP in signal transduction: cholesterol metabolism and beyond

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Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

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21 January 2018

Yin yang 1 protein negatively regulates high-density lipoprotein receptor gene transcription by disrupting binding of sterol regulatory element binding protein to the sterol regulatory element

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21 January 2018

Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1

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21 January 2018

Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein

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21 January 2018

Localization and role of NPC1L1 in cholesterol absorption in human intestine

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Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels

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7 January 2021

based on heuristic

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Sterol regulatory element binding protein-1 activates the cholesteryl ester transfer protein gene in vivo but is not required for sterol up-regulation of gene expression

1 reference

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7 January 2021

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Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe

1 reference

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7 January 2021

based on heuristic

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Yin Yang 1 Protein Negatively Regulates High-Density Lipoprotein Receptor Gene Transcription by Disrupting Binding of Sterol Regulatory Element Binding Protein to the Sterol Regulatory Element1

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https://api.crossref.org/works/10.1038%2FJHG.2009.18

7 January 2021

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10.1038/JHG.2009.18

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22 January 2020

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Europe PubMed Central

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22 January 2020

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