Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo (Q39810110)

14 September 2017

title

Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo (English)

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14 September 2017

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Cristina Bergamaschi

1

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14 September 2017

Rashmi Jalah

2

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14 September 2017

Viraj Kulkarni

3

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14 September 2017

Margherita Rosati

4

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14 September 2017

Gen-Mu Zhang

5

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14 September 2017

Candido Alicea

6

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14 September 2017

Andrei S Zolotukhin

7

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14 September 2017

Barbara K Felber

8

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14 September 2017

George N Pavlakis

9

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14 September 2017

language of work or name

English

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publication date

1 September 2009

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14 September 2017

published in

Journal of Immunology

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14 September 2017

volume

183

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14 September 2017

issue

5

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14 September 2017

page(s)

3064-3072

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Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo

14 September 2017

cites work

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12 December 2020

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

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12 December 2020

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

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12 December 2020

How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha

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12 December 2020

Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity

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12 December 2020

Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells

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12 December 2020

IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.

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12 December 2020

Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action

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12 December 2020

Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms

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12 December 2020

Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help

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12 December 2020

The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control

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12 December 2020

T cell-independent interleukin 15Ralpha signals are required for bystander proliferation

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12 December 2020

U2AF participates in the binding of TAP (NXF1) to mRNA

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12 December 2020

Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm

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12 December 2020

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice

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12 December 2020

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

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12 December 2020

Mast Cells Express Novel Functional IL-15 Receptor α Isoforms

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12 December 2020

Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells

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12 December 2020

Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes

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12 December 2020

IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels

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12 December 2020

Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA

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12 December 2020

IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

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12 December 2020

Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes

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12 December 2020

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

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12 December 2020

DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge

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12 December 2020

Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo

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12 December 2020

Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis

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12 December 2020

Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins

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12 December 2020

Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines

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12 December 2020

Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

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12 December 2020

Efficient systemic expression of bioactive IL-15 in mice upon delivery of optimized DNA expression plasmids

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12 December 2020

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translatio

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12 December 2020

A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing.

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12 December 2020

Intravenous delivery of naked plasmid DNA for in vivo cytokine expression.

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12 December 2020

The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15

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12 December 2020

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms

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12 December 2020

IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory

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12 December 2020

Expression of two interleukin-15 mRNA isoforms in human tumors does not correlate with secretion: role of different signal peptides

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12 December 2020

Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression

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12 December 2020

In vivo hydrodynamic delivery of cDNA encoding IL-2: rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells

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12 December 2020

Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation

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12 December 2020

Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0900693

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14 September 2017

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