Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. (Q39771508)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19933848%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells (English)

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12 February 2020

6

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12 February 2020

author name string

Arsene M Adon

1

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12 February 2020

Xiangbin Zeng

2

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12 February 2020

Mary K Harrison

3

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12 February 2020

Stacy Sannem

4

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12 February 2020

Hiroaki Kiyokawa

5

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12 February 2020

Harold I Saavedra

7

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12 February 2020

language of work or name

English

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publication date

23 November 2009

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Molecular and Cellular Biology

12 February 2020

published in

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12 February 2020

volume

30

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12 February 2020

issue

3

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12 February 2020

page(s)

694-710

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Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53.

12 February 2020

cites work

1 reference

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Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

22 September 2017

1 reference

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P53, cyclin-dependent kinase and abnormal amplification of centrosomes

22 September 2017

1 reference

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p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

22 September 2017

1 reference

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Plk4-induced centriole biogenesis in human cells

22 September 2017

1 reference

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Cancer drug resistance: the central role of the karyotype

22 September 2017

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Selective resistance of tetraploid cancer cells against DNA damage-induced apoptosis

22 September 2017

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Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest

22 September 2017

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

22 September 2017

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Suppression of centrosome amplification after DNA damage depends on p27 accumulation

22 September 2017

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Cyclin-dependent kinase pathways as targets for cancer treatment

22 September 2017

1 reference

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p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells

22 September 2017

1 reference

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Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis

22 September 2017

1 reference

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The antioxidant function of the p53 tumor suppressor

22 September 2017

1 reference

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Centrosome amplification, chromosome instability and cancer development

22 September 2017

1 reference

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The Polo kinase Plk4 functions in centriole duplication

22 September 2017

1 reference

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Utilization of luminescent technology to develop a kinase assay: Cdk4 as a model system

22 September 2017

1 reference

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Living with or without cyclins and cyclin-dependent kinases

22 September 2017

1 reference

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A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry

22 September 2017

1 reference

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

22 September 2017

1 reference

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MEK1 and MEK2, different regulators of the G1/S transition.

22 September 2017

1 reference

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Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies.

22 September 2017

1 reference

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Cdk2 knockout mice are viable

22 September 2017

1 reference

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Cyclin E ablation in the mouse

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Chromosome aberrations in solid tumors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Duplicating dangerously: linking centrosome duplication and aneuploidy

22 September 2017

1 reference

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CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

22 September 2017

1 reference

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Two for two: Cdk2 and its role in centrosome doubling

22 September 2017

1 reference

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

22 September 2017

1 reference

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The E2F1-3 transcription factors are essential for cellular proliferation.

22 September 2017

1 reference

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Specific protection against breast cancers by cyclin D1 ablation

22 September 2017

1 reference

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Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

22 September 2017

1 reference

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22 September 2017

Surfing the p53 network

1 reference

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Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

22 September 2017

1 reference

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Aneuploidy, the somatic mutation that makes cancer a species of its own.

22 September 2017

1 reference

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

22 September 2017

1 reference

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How aneuploidy may cause cancer and genetic instability

22 September 2017

1 reference

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The role of genomic instability in human carcinogenesis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

22 September 2017

1 reference

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

22 September 2017

1 reference

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Cyclin-dependent kinase control of centrosome duplication

22 September 2017

1 reference

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

22 September 2017

1 reference

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DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

22 September 2017

1 reference

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Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

22 September 2017

1 reference

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New functional activities for the p21 family of CDK inhibitors

22 September 2017

1 reference

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Abnormal centrosome amplification in the absence of p53.

22 September 2017

1 reference

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p21 is a universal inhibitor of cyclin kinases

22 September 2017

1 reference

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Inhibition of cyclin-dependent kinases by p21

22 September 2017

1 reference

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Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Kinetochore immunofluorescence in micronuclei: a rapid method for the in situ detection of aneuploidy and chromosome breakage in human fibroblasts

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Cdk1 is sufficient to drive the mammalian cell cycle

17 June 2018

1 reference

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Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

The mouse Mps1p-like kinase regulates centrosome duplication

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

MAPK mediates RAS-induced chromosome instability

17 June 2018

1 reference

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p21(Waf1/Cip1) deficiency stimulates centriole overduplication

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Cdc2-cyclin E complexes regulate the G1/S phase transition

20 August 2018

1 reference

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Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

Inactivation of E2F3 results in centrosome amplification

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812235

The identification of micronucleated chromosomes: a possible assay for aneuploidy

20 August 2018

1 reference

12 December 2020

Classification of micronuclei in murine erythrocytes: immunofluorescent staining using CREST antibodies compared to in situ hybridization with biotinylated gamma satellite DNA

1 reference

12 December 2020

The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway

1 reference

12 December 2020

Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

1 reference

12 December 2020

Genomic instability and apoptosis are frequent in p53 deficient young mice

1 reference

12 December 2020

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1 reference

12 December 2020

Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

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12 December 2020

Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu

1 reference

12 December 2020

Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties

1 reference

12 December 2020

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.00253-09

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19933848%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19933848%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

19933848

1 reference