α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. (Q39662647)

13 September 2017

α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. (English)

1 reference

13 September 2017

Leishmania mexicana

1 reference

Gareth D Westrop

4

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Pieter Van der Veken

object named as

Pieter Van der Veken

9

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Koen Augustyns

object named as

Koen Augustyns

11

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Jeremy C. Mottram

object named as

Jeremy C Mottram

3

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author name string

Koen Steert

1

1 reference

13 September 2017

Maya Berg

2

1 reference

13 September 2017

Graham H Coombs

5

1 reference

13 September 2017

Paul Cos

6

1 reference

13 September 2017

Louis Maes

7

1 reference

13 September 2017

Jurgen Joossens

8

1 reference

13 September 2017

Achiel Haemers

10

1 reference

13 September 2017

1 October 2010

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13 September 2017

1 reference

13 September 2017

5

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13 September 2017

10

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13 September 2017

1734-1748

1 reference

Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response

13 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Development of protease inhibitors for protozoan infections

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Protein turnover and differentiation in Leishmania.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Cysteine proteases of parasitic organisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Design and evaluation of Trypanosoma brucei metacaspase inhibitors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-phe-ala-CHN2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

The graphical determination of Km and Ki

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

17 The kinetics of reversible tight-binding inhibition

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Ketoheterocycle-based inhibitors of cathepsin K: a novel entry into the synthesis of peptidic ketoheterocycles

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Leishmania tropica: cysteine proteases are essential for growth and pathogenicity

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Concise and stereocontrolled synthesis of pseudo-C2-symmetric diamino alcohols and triamines for use in HIV protease inhibitors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245848

Electrophoretic analysis of the polypeptides of Leishmania amastigotes and promastigotes

21 August 2018

1 reference

12 December 2020

Synthesis and structure-activity relationships of peptidyl alpha-keto heterocycles as novel inhibitors of prolyl endopeptidase

1 reference

12 December 2020

Keto-1,3,4-oxadiazoles as cathepsin K inhibitors

1 reference

12 December 2020

Reactions between Weinreb amides and 2-magnesiated oxazoles: a simple and efficient preparation of 2-acyl oxazoles

1 reference

12 December 2020

N-methoxy-n-methylamides as effective acylating agents

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000265

7 January 2021

inferred from DOI database lookup

The Henry reaction: recent examples

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000265

7 January 2021

inferred from DOI database lookup

The Reactions of Primary Nitroparaffins with Isocyanates1

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000265

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/CMDC.201000265

1 reference

13 September 2017

1 reference

13 September 2017

PubMed publication ID

20799311

1 reference