The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300. (Q39595067)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

title

The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

main subject

human papilloma virus

1 reference

human papillomavirus

29 September 2024

H Zimmermann

1

1 reference

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10 December 2019

R Degenkolbe

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

H U Bernard

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

M J O'Connor

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

language of work or name

English

0 references

publication date

1 August 1999

1 reference

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10 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

volume

73

1 reference

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10 December 2019

issue

8

1 reference

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10 December 2019

page(s)

6209-6219

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300

10 December 2019

cites work

1 reference

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Inhibition of Bak-induced apoptosis by HPV-18 E6.

14 September 2017

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

14 September 2017

1 reference

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Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.

14 September 2017

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Differential roles of p300 and PCAF acetyltransferases in muscle differentiation

14 September 2017

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Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

14 September 2017

1 reference

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Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

14 September 2017

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Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

14 September 2017

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RNA Helicase A Mediates Association of CBP with RNA Polymerase II

14 September 2017

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

14 September 2017

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The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

14 September 2017

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Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

14 September 2017

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Recruitment of p300/CBP in p53-dependent signal pathways

14 September 2017

1 reference

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Binding and modulation of p53 by p300/CBP coactivators

14 September 2017

1 reference

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Synergistic activation of transcription by CBP and p53

14 September 2017

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Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

14 September 2017

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The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

14 September 2017

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

14 September 2017

1 reference

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The CBP co-activator is a histone acetyltransferase

14 September 2017

1 reference

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The transcriptional coactivators p300 and CBP are histone acetyltransferases

14 September 2017

1 reference

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YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity.

14 September 2017

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A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

14 September 2017

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Association of p300 and CBP with simian virus 40 large T antigen

14 September 2017

1 reference

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Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

14 September 2017

1 reference

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

14 September 2017

1 reference

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Inhibition of p53 DNA binding by human papillomavirus E6 proteins

14 September 2017

1 reference

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Nuclear protein CBP is a coactivator for the transcription factor CREB

14 September 2017

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Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group

14 September 2017

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Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300

14 September 2017

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Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

14 September 2017

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

14 September 2017

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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

14 September 2017

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Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

14 September 2017

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

14 September 2017

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Papillomavirus polypeptides E6 and E7 are zinc-binding proteins

14 September 2017

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

14 September 2017

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Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products

14 September 2017

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In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential

14 September 2017

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Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification

14 September 2017

1 reference

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A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18

14 September 2017

1 reference

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Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

14 September 2017

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Human papillomaviruses in the pathogenesis of anogenital cancer

14 September 2017

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Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences

14 September 2017

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The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein

14 September 2017

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Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription

14 September 2017

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Adenovirus E1A targets key regulators of cell proliferation

14 September 2017

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

14 September 2017

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T antigen is bound to a host protein in SY40-transformed cells

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

14 September 2017

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25 September 2017

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Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells

25 September 2017

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CBP-induced stimulation of c-Fos activity is abrogated by E1A.

25 September 2017

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The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

25 September 2017

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Differential use of CREB binding protein-coactivator complexes

25 September 2017

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25 September 2017

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25 September 2017

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25 September 2017

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25 September 2017

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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21 August 2018

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21 August 2018

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The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints.

21 August 2018

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HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.

21 August 2018

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E6 protein of human papillomavirus type 18 binds zinc.

21 August 2018

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Alternatively spliced HPV-18 E6* protein inhibits E6 mediated degradation of p53 and suppresses transformed cell growth

21 August 2018

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Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses

2 December 2018

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12 December 2020

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

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12 December 2020

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

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12 December 2020

HPV-18 E6 mediated inhibition of p53 DNA binding activity is independent of E6 induced degradation

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12 December 2020

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

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12 December 2020

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1 reference

12 December 2020

Oct-1 activates the epithelial-specific enhancer of human papillomavirus type 16 via a synergistic interaction with NFI at a conserved composite regulatory element

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12 December 2020

A growing coactivator network

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12 December 2020

HPV E6: ensuring all's well at the end

1 reference

12 December 2020

Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region

1 reference

12 December 2020

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1 reference

12 December 2020

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

1 reference

12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10400710%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

PubMed publication ID

10400710

1 reference