Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. (Q39559122)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

author name string

Philip M Reaper

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Matthew R Griffiths

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Joanna M Long

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Jean-Damien Charrier

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Peter A Charlton

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Julian M C Golec

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

John R Pollard

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

publication date

13 April 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

428-430

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21490603%20AND%20SRC:MED&resulttype=core&format=json

How do real tumors become resistant to cisplatin?

28 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

The DNA-damage response in human biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

ATR: an essential regulator of genome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

The combined status of ATM and p53 link tumor development with therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Patterns of somatic mutation in human cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

An oncogene-induced DNA damage model for cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Initial steps of ferulic acid polymerization by lignin peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

21 January 2018

The Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

ATR and ATRIP: partners in checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.573

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21490603

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21490603

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21490603