The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney. (Q39455165)

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15 January 2020

title

The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney (English)

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15 January 2020

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2

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15 January 2020

Odyssé Michos

4

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15 January 2020

Kai Schmidt-Ott

5

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15 January 2020

author name string

Regina Willecke

1

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15 January 2020

Katja Grossmann

3

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15 January 2020

Katharina Walentin

6

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15 January 2020

Frank Costantini

7

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15 January 2020

Walter Birchmeier

8

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15 January 2020

language of work or name

English

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publication date

8 October 2011

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15 January 2020

published in

Developmental Biology

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15 January 2020

volume

360

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15 January 2020

issue

2

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15 January 2020

page(s)

310-317

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The GDNF family: signalling, biological functions and therapeutic value

15 January 2020

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Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.

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Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

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RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

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