Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice (Q39407795)

11 September 2017

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice (English)

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11 September 2017

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3

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Thiago Yukio Kikuchi Oliveira

31 May 2020

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William R Schief

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Dennis R Burton

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Natalia T Freund

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31 May 2020

author name string

Amelia Escolano

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31 May 2020

Jon M Steichen

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31 May 2020

Daniel W Kulp

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31 May 2020

Jovana Golijanin

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31 May 2020

Devin Sok

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31 May 2020

Alexander D Gitlin

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31 May 2020

Sarina Lowe

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31 May 2020

Spencer T Chen

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31 May 2020

Jennifer Heinemann

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31 May 2020

Kai-Hui Yao

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31 May 2020

Erik Georgeson

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31 May 2020

Karen L Saye-Francisco

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31 May 2020

Yumiko Adachi

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31 May 2020

Michael Kubitz

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31 May 2020

Anna Gazumyan

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Michel C Nussenzweig

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language of work or name

English

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publication date

1 September 2016

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11 September 2017

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31 May 2020

volume

166

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31 May 2020

issue

6

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31 May 2020

page(s)

1445-1458.e12

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HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant

31 May 2020

cites work

1 reference

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HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

11 September 2017

1 reference

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A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

11 September 2017

1 reference

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Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

11 September 2017

1 reference

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HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

11 September 2017

1 reference

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Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

11 September 2017

1 reference

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Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

11 September 2017

1 reference

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Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

11 September 2017

1 reference

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HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

11 September 2017

1 reference

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HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

11 September 2017

1 reference

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Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

11 September 2017

1 reference

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Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants

11 September 2017

1 reference

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Structural evolution of glycan recognition by a family of potent HIV antibodies

11 September 2017

1 reference

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Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies

11 September 2017

1 reference

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Novel HIV vaccine strategies: overview and perspective

11 September 2017

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Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

11 September 2017

1 reference

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Structural insights on the role of antibodies in HIV-1 vaccine and therapy

11 September 2017

1 reference

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Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

11 September 2017

1 reference

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The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

11 September 2017

1 reference

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Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

11 September 2017

1 reference

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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

11 September 2017

1 reference

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Antibodies in HIV-1 vaccine development and therapy

11 September 2017

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Development of prophylactic vaccines against HIV-1.

11 September 2017

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HIV-1 neutralizing antibodies: understanding nature's pathways

11 September 2017

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Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model

11 September 2017

1 reference

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Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

11 September 2017

1 reference

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Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

11 September 2017

1 reference

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

11 September 2017

1 reference

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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

11 September 2017

1 reference

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Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

11 September 2017

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Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

11 September 2017

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Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype

11 September 2017

1 reference

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Neutralizing antibodies to HIV-1 induced by immunization.

11 September 2017

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Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs

11 September 2017

1 reference

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Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

11 September 2017

1 reference

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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.

11 September 2017

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Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

11 September 2017

1 reference

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B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

11 September 2017

1 reference

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11 September 2017

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Broad neutralization coverage of HIV by multiple highly potent antibodies

11 September 2017

1 reference

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

11 September 2017

1 reference

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Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

11 September 2017

1 reference

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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

11 September 2017

1 reference

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AID targeting in antibody diversity

11 September 2017

1 reference

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Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies

11 September 2017

1 reference

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The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection

11 September 2017

1 reference

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Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

11 September 2017

1 reference

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A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals

11 September 2017

1 reference

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Control systems and decision making for antibody production.

11 September 2017

1 reference

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

11 September 2017

1 reference

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

11 September 2017

1 reference

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Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

11 September 2017

1 reference

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Therapeutic antibodies, vaccines and antibodyomes

11 September 2017

1 reference

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Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens

11 September 2017

1 reference

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

11 September 2017

1 reference

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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

11 September 2017

1 reference

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Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates

11 September 2017

1 reference

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Sequential immunization with V3 peptides from primary human immunodeficiency virus type 1 produces cross-neutralizing antibodies against primary isolates with a matching narrow-neutralization sequence motif.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know

11 September 2017

1 reference

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Of mice and not men: differences between mouse and human immunology

11 September 2017

1 reference

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Antibody neutralization and escape by HIV-1

11 September 2017

1 reference

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Rapid evolution of the neutralizing antibody response to HIV type 1 infection

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

11 September 2017

1 reference

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Kinetic and affinity limits on antibodies produced during immune responses

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

11 September 2017

1 reference

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Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

HIV vaccine design and the neutralizing antibody problem

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Role of antigen receptor affinity in T cell-independent antibody responses in vivo

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

Low antigen dose favours selection of somatic mutants with hallmarks of antibody affinity maturation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5019122

10.1016/J.CELL.2016.07.030

21 August 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610569%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27610569%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

27610569

1 reference