Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents. (Q39369298)

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English	Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.	scientific article

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scholarly article

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27 January 2020

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents (English)

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27 January 2020

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Martin Michaelis

1

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27 January 2020

Rainer Breitling

8

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27 January 2020

Andreas von Deimling

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27 January 2020

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F Rothweiler

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27 January 2020

B Agha

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27 January 2020

S Barth

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27 January 2020

Y Voges

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27 January 2020

N Löschmann

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27 January 2020

H Wilhelm Doerr

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27 January 2020

F Rödel

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27 January 2020

D Speidel

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27 January 2020

J Cinatl

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27 January 2020

publication date

5 April 2012

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27 January 2020

Cell Death and Disease

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27 January 2020

3

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27 January 2020

e294

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27 January 2020

describes a project that uses

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UKF-NB-3rRITA10muM

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1 reference

Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/3358013

based on heuristic

inferred from PubMed Central ID database lookup

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Reactivation of p53: from peptides to small molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

11 September 2017

Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

14 September 2017

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

14 September 2017

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

14 September 2017

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

14 September 2017

Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

14 September 2017

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

14 September 2017

Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

14 September 2017

DNA damage response to the Mdm2 inhibitor nutlin-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

15 June 2018

Association of EGFR Gene Amplification and CDKN2 (p16/MTS1) Gene Deletion in Glioblastoma Multiforme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358013

15 June 2018

p53 protein accumulation and mutations in normal and benign breast tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/CDDIS.2012.35

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27 January 2020

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Europe PubMed Central

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27 January 2020

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27 January 2020

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