Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers (Q39347810)

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1 February 2020

title

Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers (English)

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1 February 2020

9

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Theodore P Nicolaides

8

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1 February 2020

author name string

Krister J Barkovich

1

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1 February 2020

Sujatmi Hariono

2

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Adam L Garske

3

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1 February 2020

Jie Zhang

4

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1 February 2020

Jimmy A Blair

5

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1 February 2020

Qi-Wen Fan

6

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Kevan M Shokat

7

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publication date

31 March 2012

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1 February 2020

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1 February 2020

volume

2

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issue

5

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1 February 2020

page(s)

450-457

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describes a project that uses

1 February 2020

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

A continuum model for tumour suppression

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Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.

11 September 2017

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Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177.

11 September 2017

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EGFR antagonists in cancer treatment

11 September 2017

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Mechanisms for oncogenic activation of the epidermal growth factor receptor

11 September 2017

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

11 September 2017

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Structure-guided development of affinity probes for tyrosine kinases using chemical genetics

11 September 2017

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Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

11 September 2017

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

11 September 2017

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

11 September 2017

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

11 September 2017

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

11 September 2017

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

11 September 2017

1 reference

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ErbB-targeted therapeutic approaches in human cancer

11 September 2017

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The ErbB receptors and their role in cancer progression.

11 September 2017

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

11 September 2017

1 reference

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Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

11 September 2017

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Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

11 September 2017

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Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3354705

10.1158/2159-8290.CD-11-0287

1 October 2018

Identifiers

DOI

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1 February 2020

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1 February 2020

PubMed publication ID

22588882

1 reference