ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence (Q39231615)

10 September 2017

title

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence (English)

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10 September 2017

Ryo Kodama

1

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Masayoshi Kato

2

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Shuichi Furuta

3

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Shouta Ueno

4

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Yugen Zhang

5

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Kuniharu Matsuno

6

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Chihiro Yabe-Nishimura

7

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Eiji Tanaka

8

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Tohru Kamata

9

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publication date

6 December 2012

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10 September 2017

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volume

18

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issue

1

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page(s)

32-41

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Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6.

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cites work

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Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a

21 January 2018

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Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts

21 January 2018

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Tumour biology: senescence in premalignant tumours

21 January 2018

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Maximizing mouse cancer models

21 January 2018

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Identification of renox, an NAD(P)H oxidase in kidney

21 January 2018

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

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NADPH oxidase 4 is an oncoprotein localized to mitochondria

21 January 2018

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p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

21 January 2018

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Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

21 January 2018

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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

21 January 2018

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NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

21 January 2018

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Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy

21 January 2018

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Regulation of Nox and Duox enzymatic activity and expression

21 January 2018

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

21 January 2018

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Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice

21 January 2018

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Base excision repair of oxidative DNA damage and association with cancer and aging

21 January 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

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The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation.

21 January 2018

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Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.

21 January 2018

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NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells.

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration.

21 January 2018

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Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

21 January 2018

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Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells

21 January 2018

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Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

21 January 2018

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ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

21 January 2018

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NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression.

21 January 2018

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Senescence comes of age

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21 January 2018

Identifiers

DOI

10.1111/GTC.12015

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10 September 2017

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