The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block (Q39175928)

13 June 2018

title

The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block (English)

1 reference

13 June 2018

author name string

Pradipta Ghosh

series ordinal

1

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13 June 2018

Padmini Rangamani

series ordinal

2

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13 June 2018

Irina Kufareva

series ordinal

3

1 reference

13 June 2018

publication date

13 March 2017

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13 June 2018

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

Cell Cycle

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13 June 2018

volume

16

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13 June 2018

issue

7

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13 June 2018

page(s)

607-612

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13 June 2018

GIV/Girdin activates Gαi and inhibits Gαs via the same motif

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1 reference

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Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation

15 June 2018

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Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy

15 June 2018

1 reference

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Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

15 June 2018

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SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins

15 June 2018

1 reference

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Signaling networks: information flow, computation, and decision making.

15 June 2018

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G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes

15 June 2018

1 reference

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Development of inhibitors of heterotrimeric Gαi subunits

15 June 2018

1 reference

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GPCR signaling along the endocytic pathway

15 June 2018

1 reference

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Conformational biosensors reveal GPCR signalling from endosomes.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin

15 June 2018

1 reference

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Spatial control of cAMP signalling in health and disease

15 June 2018

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Regulator of G protein signaling proteins as drug targets: current state and future possibilities

15 June 2018

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

15 June 2018

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G Protein Binding Sites on Calnuc (Nucleobindin 1) and NUCB2 (Nucleobindin 2) Define a New Class of Gαi-regulatory Motifs

15 June 2018

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Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif.

15 June 2018

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Structure and function of an irreversible agonist-β(2) adrenoceptor complex

15 June 2018

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Biology, blind men, and elephants

15 June 2018

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A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Activation of Galphai3 triggers cell migration via regulation of GIV.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

From components to regulatory motifs in signalling networks

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Differential targeting of Gbetagamma-subunit signaling with small molecules

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Accessory proteins for G proteins: partners in signaling.

15 June 2018

1 reference

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A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity

15 June 2018

1 reference

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Akt/PKB regulates actin organization and cell motility via Girdin/APE

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

The regulator of G protein signaling family

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5397260

10.1080/15384101.2017.1282584

17 June 2018

Identifiers

DOI

1 reference

13 June 2018

PMC publication ID

5397260

1 reference

13 June 2018

PubMed publication ID

28287365

1 reference

13 June 2018