Exploring the IL-21-STAT3 axis as therapeutic target for Sézary syndrome. (Q39001895)

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15 March 2020

title

Exploring the IL-21-STAT3 axis as therapeutic target for Sézary syndrome (English)

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15 March 2020

4

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15 March 2020

author name string

Leslie van der Fits

1

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15 March 2020

Jacoba J Out-Luiting

2

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15 March 2020

Cornelis P Tensen

3

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15 March 2020

Maarten H Vermeer

5

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15 March 2020

language of work or name

English

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publication date

22 April 2014

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Journal of Investigative Dermatology

15 March 2020

published in

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volume

134

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15 March 2020

issue

10

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page(s)

2639-2647

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STAT3 as a central mediator of neoplastic cellular transformation

15 March 2020

cites work

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12 December 2020

Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages.

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12 December 2020

Autocrine IL-21 Stimulation Is Involved in the Maintenance of Constitutive STAT3 Activation in Sézary Syndrome

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12 December 2020

WHO-EORTC classification for cutaneous lymphomas

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12 December 2020

Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function

1 reference

12 December 2020

Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer

1 reference

12 December 2020

Autocrine regulation of IL-21 production in human T lymphocytes

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12 December 2020

Sézary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain)

1 reference

12 December 2020

Novel and highly recurrent chromosomal alterations in Sézary syndrome.

1 reference

12 December 2020

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

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12 December 2020

Interleukin-21 signaling: functions in cancer and autoimmunity

1 reference

12 December 2020

Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells

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12 December 2020

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

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12 December 2020

Interleukin-21 is a growth and survival factor for human myeloma cells

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12 December 2020

A continuous T-cell line from a patient with Sézary syndrome

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12 December 2020

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

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12 December 2020

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome

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12 December 2020

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

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12 December 2020

Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells

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12 December 2020

Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis

1 reference

12 December 2020

Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment

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12 December 2020

Signaling by IL-31 and functional consequences

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12 December 2020

A meta-analysis of gene expression data identifies a molecular signature characteristic for tumor-stage mycosis fungoides.

1 reference

12 December 2020

MicroRNA-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sézary syndrome.

1 reference

12 December 2020

Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease

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12 December 2020

Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy

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12 December 2020

The STATs of cancer--new molecular targets come of age

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12 December 2020

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12 December 2020

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

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12 December 2020

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha

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12 December 2020

Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy

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12 December 2020

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

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12 December 2020

Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

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12 December 2020

IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma

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12 December 2020

Roles of unphosphorylated STATs in signaling

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12 December 2020

IL-21 Enhances Antitumor Responses without Stimulating Proliferation of Malignant T Cells of Patients with Sézary Syndrome

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12 December 2020

Serum IL-31 levels are increased in patients with cutaneous T-cell lymphoma

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12 December 2020

Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

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12 December 2020

Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells

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12 December 2020

The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

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12 December 2020

Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells

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12 December 2020

The JAK-STAT signaling pathway: input and output integration

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12 December 2020

Identifiers

DOI

10.1038/JID.2014.199

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15 March 2020

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