Bryostatin-1 causes radiosensitization of BMG-1 malignant glioma cells through differential activation of protein kinase-Cδ not evident in the non-malignant AA8 fibroblasts (Q38932379)

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English	Bryostatin-1 causes radiosensitization of BMG-1 malignant glioma cells through differential activation of protein kinase-Cδ not evident in the non-malignant AA8 fibroblasts	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

Bryostatin-1 causes radiosensitization of BMG-1 malignant glioma cells through differential activation of protein kinase-Cδ not evident in the non-malignant AA8 fibroblasts (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

1 reference

ChEBI release 2020-05-28

Raghubendra Singh Dagur

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25472878%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25472878%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Shashank Hambarde

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25472878%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

4 December 2014

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

Molecular and Cellular Biochemistry

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25472878%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

401

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25472878%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25472878%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

49-59

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25472878%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentation in human myelomonocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937).

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Modulation of ara-C induced apoptosis in leukemia by the PKC activator bryostatin 1.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Chronic exposure to bryostatin-1 increases the radiosensitivity of U937 leukaemia cells ectopically expressing Bcl-2 through a non-apoptotic mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Radiosensitization of HL-60 human leukaemia cells by bryostatin-1 in the absence of increased DNA fragmentation or apoptotic cell death

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

A phase I study of intravenous bryostatin 1 in patients with advanced cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Phase I study of bryostatin 1, a protein kinase C modulator, preceding cisplatin in patients with refractory non-hematologic tumors

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Stress response of a p53 homologue in the radioresistant Sf9 insect cells.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Activation of protein kinase C delta by all-trans-retinoic acid

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Protein kinase C-delta regulates migration and proliferation of vascular smooth muscle cells through the extracellular signal-regulated kinase 1/2.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Characterization of cis-acting elements of the gene for macrophage-stimulating protein from the human. The involvement of positive and negative regulatory elements.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11010-014-2291-0

21 January 2018

Rapid protein phosphorylation induced by phorbol ester in HL-60 cells. Unique alkali-stable phosphorylation of a 17,000-dalton protein detected by two-dimensional gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 and protein kinase C independent induction of growth arrest and apoptosis by bryostatin 1 in a highly metastatic mammary epithelial cell line: In vitro versus in vivo activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the protein kinase C stimulant bryostatin 1 on the proliferation and colony formation of irradiated human T-lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and clinical experience with bryostatin 1: a novel anticancer drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol ester tumor-promoting agents and membrane stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/25472878

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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