Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells (Q38901805)

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scientific article published on March 21, 2011

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English	Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells	scientific article published on March 21, 2011

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scholarly article

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PMC publication ID

7 September 2017

Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells (English)

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7 September 2017

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alveolar rhabdomyosarcoma

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Y. Zhang

1

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27 November 2024

C. Wang

2

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27 November 2024

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21 March 2011

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7 September 2017

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https://www.nature.com/articles/onc201169.pdf

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27 November 2024

https://europepmc.org/articles/PMC3205923

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https://europepmc.org/articles/PMC3205923?pdf=render

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21423212

27 November 2024

https://doi.org/10.1038/onc.2011.69

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21423212

27 November 2024

http://www.nature.com/articles/onc201169.pdf

1 reference

10.1038/ONC.2011.69

https://api.crossref.org/works/10.1038/ONC.2011.69

27 November 2024

http://www.nature.com/articles/onc201169

1 reference

10.1038/ONC.2011.69

https://api.crossref.org/works/10.1038/ONC.2011.69

27 November 2024

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

30

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

32

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

3549-3562

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

The insulin-like growth factor system and sarcomas.

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9 September 2017

Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group

1 reference

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9 September 2017

Role of CCN, a vertebrate specific gene family, in development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

The CCN family of proteins: structure-function relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma

1 reference

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9 September 2017

Role for amplification and expression of glypican-5 in rhabdomyosarcoma

1 reference

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9 September 2017

The CCN3 protein and cancer

2 references

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9 September 2017

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21 January 2018

In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

CCN proteins: multifunctional signalling regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

The expression of ccn3(nov) gene in musculoskeletal tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

The COOH-terminal transactivation domain plays a key role in regulating the in vitro and in vivo function of Pax3 homeodomain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Common musculoskeletal tumors of childhood and adolescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

The CCN family of angiogenic regulators: the integrin connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Identification of a new binding motif for the paired domain of Pax-3 and unusual characteristics of spacing of bipartite recognition elements on binding and transcription activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Pax3 modulates expression of the c-Met receptor during limb muscle development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations

1 reference

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9 September 2017

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

9 September 2017

Pax-3 contains domains for transcription activation and transcription inhibition

1 reference

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9 September 2017

Pax3 inhibits myogenic differentiation of cultured myoblast cells

1 reference

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9 September 2017

Identification of DNA recognition sequences for the Pax3 paired domain

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9 September 2017

Proviral Rearrangements and Overexpression of a New Cellular Gene (nov) in Myeloblastosis-Associated Virus Type 1-Induced Nephroblastomas

1 reference

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9 September 2017

The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain.

1 reference

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9 September 2017

The CCN family of genes: a perspective on CCN biology and therapeutic potential

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14 September 2017

Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor

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14 September 2017

The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor

1 reference

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14 September 2017

Nuclear addressing provides a clue for the transforming activity of amino-truncated CCN3 proteins

1 reference

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14 September 2017

The cooperative transforming effects of PAX3-FKHR and IGF-II on mouse myoblasts.

1 reference

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14 September 2017

Inhibition of connective tissue growth factor (CTGF/CCN2) expression decreases the survival and myogenic differentiation of human rhabdomyosarcoma cells

1 reference

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14 September 2017

NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR‐α‐dependent mechanism

1 reference

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14 September 2017

PAX3/forkhead homolog in rhabdomyosarcoma oncoprotein activates glucose transporter 4 gene expression in vivo and in vitro.

1 reference

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14 September 2017

Alternative splicing of CCN mRNAs .... it has been upon us.

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17 June 2018

CCN3: Doctor Jekyll and Mister Hyde

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17 June 2018

Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain

1 reference

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17 June 2018

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1 reference

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17 June 2018

A new marker for rhabdomyosarcoma. Insulin-like growth factor II

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17 June 2018

Comparative analysis of paired- and homeodomain-specific roles in PAX3-FKHR oncogenesis

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22 August 2018

Matricellular CCN proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

22 August 2018

NOV/CCN3 impairs muscle cell commitment and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

22 August 2018

NOV/CCN3 induces adhesion of muscle skeletal cells and cooperates with FGF2 and IGF-1 to promote proliferation and survival.

1 reference

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22 August 2018

Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding

1 reference

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22 August 2018

The CCN family of genes: a brief history

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22 August 2018

Mouse Nov gene is expressed in hypaxial musculature and cranial structures derived from neural crest cells and placodes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205923

22 August 2018

Expression of connective tissue growth factor (CTGF/CCN2) in a mouse model of rhabdomyosarcomagenesis

1 reference

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4 November 2018

Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.69

31 March 2020

Different pattern of matrix metalloproteinases expression in alveolar versus embryonal rhabdomyosarcoma

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https://api.crossref.org/works/10.1038%2FONC.2011.69

31 March 2020

Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.69

31 March 2020

Consistent chromosomal translocation in alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.69

31 March 2020

The paired-domain regulates DNA binding by the homeodomain within the intact Pax-3 protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.69

31 March 2020

[The CCN family of cell growth regulators: a new family of normal and pathologic cell growth and differentiation regulators: lessons from the first international workshop on CCN gene family]

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12 December 2020

based on heuristic

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Chromosomal analysis of sixteen human rhabdomyosarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21423212

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Journal of Clinical Investigation

19

119

1558

author name string

AD Durbin

publication date

2009

1 reference

10.1038/ONC.2011.69

https://api.crossref.org/works/10.1038/ONC.2011.69

27 November 2024

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10.1038/ONC.2011.69

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

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