Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes (Q38896410)

7 September 2017

title

Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes (English)

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7 September 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

J-A Choi

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

J Y Kim

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

H M Kim

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

I K Lim

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

23 March 2015

1 reference

7 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

1

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7 June 2020

page(s)

83-93

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25798836%20AND%20SRC:MED&resulttype=core&format=json

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

7 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Cellular motility driven by assembly and disassembly of actin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Cell migration: integrating signals from front to back

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

The formins: active scaffolds that remodel the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

TIS21/BTG2 inhibits invadopodia formation by downregulating reactive oxygen species level in MDA-MB-231 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

TIS21/(BTG2) negatively regulates estradiol-stimulated expansion of hematopoietic stem cells by derepressing Akt phosphorylation and inhibiting mTOR signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

The cofilin pathway in breast cancer invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFκB pathways which enhances transcription of MnSOD by accelerating IκBα degradation in normal and cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

PI3K and cancer: lessons, challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

BTG2 suppresses cancer cell migration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Expression of B-cell translocation gene 2 protein in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

BTG2 loss and miR-21 upregulation contribute to prostate cell transformation by inducing luminal markers expression and epithelial-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Distinct biological roles for the akt family in mammary tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Synaptotagmin-mediated vesicle fusion regulates cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Regulation of Btg2(/TIS21/PC3) expression via reactive oxygen species-protein kinase C-ΝFκΒ pathway under stress conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Differential expression of TIS21 and TIS1 genes in the various organs of Balb/c mice, thymic carcinoma tissues and human cancer cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

The humoral immune system has a key prognostic impact in node-negative breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.64

Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25798836

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Knock-down of P-glycoprotein reverses taxol resistance in ovarian cancer multicellular spheroids

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25798836

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25798836