Biology and relevance of human acute myeloid leukemia stem cells (Q38761783)

20 May 2018

title

Biology and relevance of human acute myeloid leukemia stem cells (English)

1 reference

20 May 2018

main subject

acute myeloid leukemia

1 reference

Daniel Thomas

1

1 reference

20 May 2018

Ravindra Majeti

series ordinal

2

1 reference

20 May 2018

language of work or name

English

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publication date

3 February 2017

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20 May 2018

number of pages

9

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inferred from page(s)

published in

Blood

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20 May 2018

volume

129

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20 May 2018

issue

12

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20 May 2018

page(s)

1577-1585

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20 May 2018

inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice

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Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

23 June 2018

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Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

23 June 2018

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Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias.

23 June 2018

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Genomic Classification and Prognosis in Acute Myeloid Leukemia

23 June 2018

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A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

23 June 2018

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GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.

23 June 2018

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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells

23 June 2018

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An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

23 June 2018

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Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

23 June 2018

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CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia

23 June 2018

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23 June 2018

Acute Myeloid Leukemia

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Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

23 June 2018

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The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential

23 June 2018

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Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

23 June 2018

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Xenograft models for normal and malignant stem cells

23 June 2018

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Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

23 June 2018

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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

23 June 2018

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23 June 2018

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Immunogenetics. Chromatin state dynamics during blood formation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Metabolic requirements for the maintenance of self-renewing stem cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Evolution of the cancer stem cell model

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells

23 June 2018

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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

23 June 2018

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

23 June 2018

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

23 June 2018

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BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

23 June 2018

1 reference

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

23 June 2018

1 reference

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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

23 June 2018

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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

23 June 2018

1 reference

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Frequency of leukemic initiating cells does not depend on the xenotransplantation model used

23 June 2018

1 reference

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Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

23 June 2018

1 reference

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Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

23 June 2018

1 reference

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Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

23 June 2018

1 reference

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CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

23 June 2018

1 reference

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Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

23 June 2018

1 reference

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The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells

23 June 2018

1 reference

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CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia

23 June 2018

1 reference

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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

23 June 2018

1 reference

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

23 June 2018

1 reference

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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

23 June 2018

1 reference

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival

23 June 2018

1 reference

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Acute myeloid leukemia stem cells

23 June 2018

1 reference

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Acute promyelocytic leukemia: where does it stem from?

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML).

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Stem cells, cancer, and cancer stem cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Review of recent studies of cellular proliferation in acute leukemia.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Colony formation in vitro by myelomonocytic leukemic cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Studies of Cellular Proliferation in Human Leukemia. I. Estimation of Growth Rates of Leukemic and Normal Hematopoietic Cells in Two Adults with Acute Leukemia Given Single Injections of Tritiated Thymidine *

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

In vitro colony formation by normal and leukemic human hematopoietic cells: characterization of the colony-forming cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Stem cell gene expression programs influence clinical outcome in human leukemia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5364335

Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982).

31 August 2018

1 reference

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Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ−/− mice

31 August 2018

1 reference

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Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia

3 December 2018

1 reference

12 December 2020

COLONY ASSAY FOR PROLIFERATIVE BLAST CELLS CIRCULATING IN MYELOBLASTIC LEUKÆMIA

1 reference

12 December 2020

Detection and characterization of primitive malignant and normal progenitors in patients with acute myelogenous leukemia using long-term coculture with supportive feeder layers and cytokines

1 reference

12 December 2020

Identification of variables determining the engraftment potential of human acute myeloid leukemia in the immunodeficient NOD/SCID human chimera model

1 reference

12 December 2020

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

1 reference

12 December 2020

Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes

1 reference

12 December 2020

CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

1 reference

12 December 2020

Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture

1 reference

12 December 2020

10.1182/BLOOD-2016-10-696054

Identifiers

DOI

1 reference

20 May 2018

PMC publication ID

5364335

1 reference

20 May 2018

PubMed publication ID

28159741

1 reference

20 May 2018